The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition

Johanna M. Jarcho; Nathan A. Fox; Daniel S. Pine; Amit Etkin; Ellen Leibenluft; Tomer Shechner; Monique Ernst

doi:10.1016/j.biopsycho.2012.09.008

The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition

Johanna M. Jarcho, Nathan A. Fox, Daniel S. Pine, Amit Etkin, Ellen Leibenluft, Tomer Shechner, Monique Ernst

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The present study is the first to assess whether the neural correlates of cognitive control processes differ in adults with and without a behaviorally inhibited temperament during early childhood. Adults with and without childhood behavioral inhibition completed an emotional conflict task while undergoing functional magnetic resonance imaging scanning. While no group differences in behavior were observed, adults with childhood behavioral inhibition, relative to adults without childhood behavioral inhibition, exhibited greater dorsomedial prefrontal cortex activity during conflict detection and greater putamen activity during conflict adaptation. Lifetime psychopathology predicted behavioral, but not brain-related, differences in conflict adaptation. These data suggest that the brain regions underlying cognitive control processes are differentially influenced by childhood behavioral inhibition, and may be differently related to psychopathology.

Original language	English (US)
Pages (from-to)	306-314
Number of pages	9
Journal	Biological Psychology
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/j.biopsycho.2012.09.008
State	Published - Feb 2013
Externally published	Yes

Keywords

Behavioral inhibition
Conflict adaptation
Conflict detection
Development
Emotion regulation
FMRI

ASJC Scopus subject areas

General Neuroscience
Neuropsychology and Physiological Psychology

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10.1016/j.biopsycho.2012.09.008

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title = "The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition",

abstract = "The present study is the first to assess whether the neural correlates of cognitive control processes differ in adults with and without a behaviorally inhibited temperament during early childhood. Adults with and without childhood behavioral inhibition completed an emotional conflict task while undergoing functional magnetic resonance imaging scanning. While no group differences in behavior were observed, adults with childhood behavioral inhibition, relative to adults without childhood behavioral inhibition, exhibited greater dorsomedial prefrontal cortex activity during conflict detection and greater putamen activity during conflict adaptation. Lifetime psychopathology predicted behavioral, but not brain-related, differences in conflict adaptation. These data suggest that the brain regions underlying cognitive control processes are differentially influenced by childhood behavioral inhibition, and may be differently related to psychopathology.",

keywords = "Behavioral inhibition, Conflict adaptation, Conflict detection, Development, Emotion regulation, FMRI",

author = "Jarcho, {Johanna M.} and Fox, {Nathan A.} and Pine, {Daniel S.} and Amit Etkin and Ellen Leibenluft and Tomer Shechner and Monique Ernst",

note = "Funding Information: This work was supported by the Intramural Research Program of the National Institute of Health , and grants from the National Institute of Mental Health Grant (NAF: R01 MH 074454 ) and the National Institute of Child Health and Development Grant (NAF: 5R37 HD 017899-20 ).",

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AU - Fox, Nathan A.

AU - Pine, Daniel S.

AU - Etkin, Amit

AU - Leibenluft, Ellen

AU - Shechner, Tomer

AU - Ernst, Monique

N1 - Funding Information: This work was supported by the Intramural Research Program of the National Institute of Health , and grants from the National Institute of Mental Health Grant (NAF: R01 MH 074454 ) and the National Institute of Child Health and Development Grant (NAF: 5R37 HD 017899-20 ).

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AB - The present study is the first to assess whether the neural correlates of cognitive control processes differ in adults with and without a behaviorally inhibited temperament during early childhood. Adults with and without childhood behavioral inhibition completed an emotional conflict task while undergoing functional magnetic resonance imaging scanning. While no group differences in behavior were observed, adults with childhood behavioral inhibition, relative to adults without childhood behavioral inhibition, exhibited greater dorsomedial prefrontal cortex activity during conflict detection and greater putamen activity during conflict adaptation. Lifetime psychopathology predicted behavioral, but not brain-related, differences in conflict adaptation. These data suggest that the brain regions underlying cognitive control processes are differentially influenced by childhood behavioral inhibition, and may be differently related to psychopathology.

KW - Behavioral inhibition

KW - Conflict adaptation

KW - Conflict detection

KW - Development

KW - Emotion regulation

KW - FMRI

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The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition

Abstract

Keywords

ASJC Scopus subject areas

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