The nature of retinoblastoma. I. Photoreceptor differentiation: A clinical and histopathologic study

Mark O.M. Ts'o, Lorenz E. Zimmerman, Ben S. Fine

Research output: Contribution to journalArticlepeer-review

Abstract

An unusual form of differentiation was observed in 18 retinoblastomas. In these neoplasms, certain tumor cells differed morphologically from the undifferentiated retinoblastoma cells and also from those forming the Flexner-Wintersteiner rosettes. These cells exhibited more advanced differentiation and produced unequivocal photoreceptor elements. Cytologically, these highly differentiated tumor cells are considered less anaplastic. Such a cytologic impression is supported by the followup clinical data.

Original languageEnglish (US)
Pages (from-to)339-349
Number of pages11
JournalAmerican journal of ophthalmology
Volume69
Issue number3
DOIs
StatePublished - Mar 1970
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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