The natural polyamine spermine functions directly as a free radical scavenger

Hyo Chol Ha, Nilantha S. Sirisoma, Periannan Kuppusamy, Jay L. Zweier, Patrick M. Woster, Robert A Casero

Research output: Contribution to journalArticle

Abstract

The polyamines are small organic cations that are absolutely required for eukaryotic cell growth. Although their growth requirements are well established, the molecular functions of the polyamines are ill-defined. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. The polyamine spermine, which is normally found in millimolar concentrations in the nucleus, is shown here to function directly as a free radical scavenger, and adducts formed as a result of this function are identified. These data suggest that spermine is a major natural intracellular compound capable of protecting DNA from free radical attack.

Original languageEnglish (US)
Pages (from-to)11140-11145
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number19
DOIs
StatePublished - Sep 15 1998

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Free Radical Scavengers
Spermine
Polyamines
Eukaryotic Cells
Growth
DNA Damage
Free Radicals
Cations
Reactive Oxygen Species
DNA

ASJC Scopus subject areas

  • Genetics
  • General

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The natural polyamine spermine functions directly as a free radical scavenger. / Ha, Hyo Chol; Sirisoma, Nilantha S.; Kuppusamy, Periannan; Zweier, Jay L.; Woster, Patrick M.; Casero, Robert A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 19, 15.09.1998, p. 11140-11145.

Research output: Contribution to journalArticle

Ha, Hyo Chol ; Sirisoma, Nilantha S. ; Kuppusamy, Periannan ; Zweier, Jay L. ; Woster, Patrick M. ; Casero, Robert A. / The natural polyamine spermine functions directly as a free radical scavenger. In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 19. pp. 11140-11145.
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