The natural history of metastatic progression in men with prostate-specific antigen recurrence after radical prostatectomy: Long-term follow-up

Research output: Contribution to journalArticle

Abstract

Objective: To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. Patients and Methods: We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiary hospital between July 1981 and July 2010 who developed PSA recurrence (≥0.2 ng/mL) and never received adjuvant or salvage therapy before the development of metastatic disease. We estimated MFS using the Kaplan-Meier method, and investigated factors influencing the risk of metastasis using Cox proportional hazards regression. Results: Median follow-up after prostatectomy was 8.0 years, and after biochemical recurrence was 4.0 years. At last follow-up, 134 of 450 patients (29.8%) had developed metastases, while median MFS was 10.0 years. Using multivariable regressions, two variables emerged as independently predictive of MFS: PSA doubling time (

LanguageEnglish (US)
Pages32-39
Number of pages8
JournalBJU International
Volume109
Issue number1
DOIs
StatePublished - Jan 2012

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Prostate-Specific Antigen
Prostatectomy
Natural History
Neoplasm Metastasis
Recurrence
Survival
Salvage Therapy
Tertiary Care Centers

Keywords

  • metastasis-free survival
  • natural history
  • prostate cancer
  • PSA recurrence

ASJC Scopus subject areas

  • Urology

Cite this

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title = "The natural history of metastatic progression in men with prostate-specific antigen recurrence after radical prostatectomy: Long-term follow-up",
abstract = "Objective: To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. Patients and Methods: We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiary hospital between July 1981 and July 2010 who developed PSA recurrence (≥0.2 ng/mL) and never received adjuvant or salvage therapy before the development of metastatic disease. We estimated MFS using the Kaplan-Meier method, and investigated factors influencing the risk of metastasis using Cox proportional hazards regression. Results: Median follow-up after prostatectomy was 8.0 years, and after biochemical recurrence was 4.0 years. At last follow-up, 134 of 450 patients (29.8{\%}) had developed metastases, while median MFS was 10.0 years. Using multivariable regressions, two variables emerged as independently predictive of MFS: PSA doubling time (",
keywords = "metastasis-free survival, natural history, prostate cancer, PSA recurrence",
author = "Antonarakis, {Emmanuel S.} and Zhaoyong Feng and Trock, {Bruce J.} and Humphreys, {Elizabeth B.} and Carducci, {Michael A.} and Partin, {Alan W.} and Walsh, {Patrick C.} and Eisenberger, {Mario A.}",
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T2 - BJU International

AU - Antonarakis,Emmanuel S.

AU - Feng,Zhaoyong

AU - Trock,Bruce J.

AU - Humphreys,Elizabeth B.

AU - Carducci,Michael A.

AU - Partin,Alan W.

AU - Walsh,Patrick C.

AU - Eisenberger,Mario A.

PY - 2012/1

Y1 - 2012/1

N2 - Objective: To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. Patients and Methods: We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiary hospital between July 1981 and July 2010 who developed PSA recurrence (≥0.2 ng/mL) and never received adjuvant or salvage therapy before the development of metastatic disease. We estimated MFS using the Kaplan-Meier method, and investigated factors influencing the risk of metastasis using Cox proportional hazards regression. Results: Median follow-up after prostatectomy was 8.0 years, and after biochemical recurrence was 4.0 years. At last follow-up, 134 of 450 patients (29.8%) had developed metastases, while median MFS was 10.0 years. Using multivariable regressions, two variables emerged as independently predictive of MFS: PSA doubling time (

AB - Objective: To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. Patients and Methods: We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiary hospital between July 1981 and July 2010 who developed PSA recurrence (≥0.2 ng/mL) and never received adjuvant or salvage therapy before the development of metastatic disease. We estimated MFS using the Kaplan-Meier method, and investigated factors influencing the risk of metastasis using Cox proportional hazards regression. Results: Median follow-up after prostatectomy was 8.0 years, and after biochemical recurrence was 4.0 years. At last follow-up, 134 of 450 patients (29.8%) had developed metastases, while median MFS was 10.0 years. Using multivariable regressions, two variables emerged as independently predictive of MFS: PSA doubling time (

KW - metastasis-free survival

KW - natural history

KW - prostate cancer

KW - PSA recurrence

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