The Natural History of HIV-1 Infection in Young Thai Men after Seroconversion

Ram Rangsin, Joseph Chiu, Chirasak Khamboonruang, Narongrid Sirisopana, Sakol Eiumtrakul, Arthur E. Brown, Merlin Robb, Christopher Beyrer, Cholticha Ruangyuttikarn, Lauri E. Markowitz, Kenrad Edwin Nelson

Research output: Contribution to journalArticle

Abstract

The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 + cell count of

Original languageEnglish (US)
Pages (from-to)622-629
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume36
Issue number1
DOIs
StatePublished - May 1 2004

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Keywords

  • HIV infection progression
  • HIV-1 infection survival
  • HIV-1 subtype E (CRF01_AE)
  • Natural history of HIV-1
  • Thailand

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Rangsin, R., Chiu, J., Khamboonruang, C., Sirisopana, N., Eiumtrakul, S., Brown, A. E., Robb, M., Beyrer, C., Ruangyuttikarn, C., Markowitz, L. E., & Nelson, K. E. (2004). The Natural History of HIV-1 Infection in Young Thai Men after Seroconversion. Journal of Acquired Immune Deficiency Syndromes, 36(1), 622-629. https://doi.org/10.1097/00126334-200405010-00011