TY - JOUR
T1 - The Natural History of HIV-1 Infection in Young Thai Men after Seroconversion
AU - Rangsin, Ram
AU - Chiu, Joseph
AU - Khamboonruang, Chirasak
AU - Sirisopana, Narongrid
AU - Eiumtrakul, Sakol
AU - Brown, Arthur E.
AU - Robb, Merlin
AU - Beyrer, Chris
AU - Ruangyuttikarn, Cholticha
AU - Markowitz, Lauri E.
AU - Nelson, Kenrad E.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 + cell count of <200/μL was 7.4 years and 6.9 years, respectively. The mortality rate was 56.3 deaths per 1000 patient-years for HIV-positive men and 6.1 deaths per 1000 patient-years for HIV-negative men. Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.
AB - The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 + cell count of <200/μL was 7.4 years and 6.9 years, respectively. The mortality rate was 56.3 deaths per 1000 patient-years for HIV-positive men and 6.1 deaths per 1000 patient-years for HIV-negative men. Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.
KW - HIV infection progression
KW - HIV-1 infection survival
KW - HIV-1 subtype E (CRF01_AE)
KW - Natural history of HIV-1
KW - Thailand
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U2 - 10.1097/00126334-200405010-00011
DO - 10.1097/00126334-200405010-00011
M3 - Article
C2 - 15097306
AN - SCOPUS:11144358256
SN - 1525-4135
VL - 36
SP - 622
EP - 629
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 1
ER -