The natural history of Hepatitis C virus infection

Host, viral, and environmental factors

David L Thomas, Jacquie Astemborski, Rudra M. Rai, Frank A. Anania, Melody Schaeffer, Noya Galai, Karen Nolt, Kenrad Edwin Nelson, Steffanie A. Strathdee, Lisette Johnson, Oliver B. Laeyendecker, John Boitnott, Lucy E. Wilson, David Vlahov

Research output: Contribution to journalArticle

Abstract

Context: Hepatitis C virus (HCV) infection may resolve (viral clearance), persist without complications, or cause end-stage liver disease (ESLD). The frequency and determinants of these outcomes are poorly understood. Objective: To assess the incidence and determinants of viral clearance and ESLD among persons who acquired HCV infection from injection drug use. Design and Setting: Community-based prospective cohort study with enrollment in 1988-1989 and a median follow-up of 8.8 years. Subjects A total of 1667 persons aged 17 years or older with a history of injection drug use and an HCV antibody-positive test result during follow-up. Main Outcome Measures: Viral clearance was assessed in a subset of 919 patients and defined as failure to detect HCV RNA in at least 2 consecutive samples collected 5 or more months apart. End-stage liver disease was assessed at semiannual visits and by review of medical records and death certificates and defined by the presence of ascites, esophageal varices, or hepatic encephalopathy, or when ESLD was stated as a cause of death. Results: Viral clearance was observed in 90 persons who were compared with 722 with persistent viremia, while the viremia of 107 was not resolved. Viral clearance occurred more often in nonblacks (adjusted odds ratio [OR], 5.15; 95% confidence interval [Cl], 2.60-10.17) and those not infected with human immunodeficiency virus (HIV) (adjusted OR, 2.19; 95% Cl, 1.26-3.47). Forty cases of ESLD were observed throughout follow-up (incidence, 3.1 per 1000 person-years). In a multivariate model, risk of ESLD was higher for persons aged 38 years or older at enrollment (adjusted relative incidence, 3.67; 95% Cl, 1.96-6.88) and who reported ingestion of more than 260 g of alcohol per week (adjusted relative incidence, 3.60; 95% Cl, 1.73-7.52). Of 210 patients without ESLD randomly selected for biopsy, only 2 had cirrhosis. Conclusions: Our results indicate that although HCV infection can be self-limited or associated with ESLD, the majority of adults have persistent viremia without clinically demonstrable liver disease. Further research is needed to explain the less frequent clearance of HCV infection among black persons and to improve utilization of treatment for those infected in the context of injection drug use.

Original languageEnglish (US)
Pages (from-to)450-456
Number of pages7
JournalJournal of the American Medical Association
Volume284
Issue number4
StatePublished - Jul 26 2000

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End Stage Liver Disease
Virus Diseases
Natural History
Hepacivirus
Viremia
Incidence
Injections
Odds Ratio
Pharmaceutical Preparations
Death Certificates
Hepatitis C Antibodies
Hepatic Encephalopathy
Esophageal and Gastric Varices
Ascites
Medical Records
Liver Diseases
Cause of Death
Fibrosis
Cohort Studies
Eating

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thomas, D. L., Astemborski, J., Rai, R. M., Anania, F. A., Schaeffer, M., Galai, N., ... Vlahov, D. (2000). The natural history of Hepatitis C virus infection: Host, viral, and environmental factors. Journal of the American Medical Association, 284(4), 450-456.

The natural history of Hepatitis C virus infection : Host, viral, and environmental factors. / Thomas, David L; Astemborski, Jacquie; Rai, Rudra M.; Anania, Frank A.; Schaeffer, Melody; Galai, Noya; Nolt, Karen; Nelson, Kenrad Edwin; Strathdee, Steffanie A.; Johnson, Lisette; Laeyendecker, Oliver B.; Boitnott, John; Wilson, Lucy E.; Vlahov, David.

In: Journal of the American Medical Association, Vol. 284, No. 4, 26.07.2000, p. 450-456.

Research output: Contribution to journalArticle

Thomas, DL, Astemborski, J, Rai, RM, Anania, FA, Schaeffer, M, Galai, N, Nolt, K, Nelson, KE, Strathdee, SA, Johnson, L, Laeyendecker, OB, Boitnott, J, Wilson, LE & Vlahov, D 2000, 'The natural history of Hepatitis C virus infection: Host, viral, and environmental factors', Journal of the American Medical Association, vol. 284, no. 4, pp. 450-456.
Thomas, David L ; Astemborski, Jacquie ; Rai, Rudra M. ; Anania, Frank A. ; Schaeffer, Melody ; Galai, Noya ; Nolt, Karen ; Nelson, Kenrad Edwin ; Strathdee, Steffanie A. ; Johnson, Lisette ; Laeyendecker, Oliver B. ; Boitnott, John ; Wilson, Lucy E. ; Vlahov, David. / The natural history of Hepatitis C virus infection : Host, viral, and environmental factors. In: Journal of the American Medical Association. 2000 ; Vol. 284, No. 4. pp. 450-456.
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AU - Anania, Frank A.

AU - Schaeffer, Melody

AU - Galai, Noya

AU - Nolt, Karen

AU - Nelson, Kenrad Edwin

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AU - Johnson, Lisette

AU - Laeyendecker, Oliver B.

AU - Boitnott, John

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AU - Vlahov, David

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N2 - Context: Hepatitis C virus (HCV) infection may resolve (viral clearance), persist without complications, or cause end-stage liver disease (ESLD). The frequency and determinants of these outcomes are poorly understood. Objective: To assess the incidence and determinants of viral clearance and ESLD among persons who acquired HCV infection from injection drug use. Design and Setting: Community-based prospective cohort study with enrollment in 1988-1989 and a median follow-up of 8.8 years. Subjects A total of 1667 persons aged 17 years or older with a history of injection drug use and an HCV antibody-positive test result during follow-up. Main Outcome Measures: Viral clearance was assessed in a subset of 919 patients and defined as failure to detect HCV RNA in at least 2 consecutive samples collected 5 or more months apart. End-stage liver disease was assessed at semiannual visits and by review of medical records and death certificates and defined by the presence of ascites, esophageal varices, or hepatic encephalopathy, or when ESLD was stated as a cause of death. Results: Viral clearance was observed in 90 persons who were compared with 722 with persistent viremia, while the viremia of 107 was not resolved. Viral clearance occurred more often in nonblacks (adjusted odds ratio [OR], 5.15; 95% confidence interval [Cl], 2.60-10.17) and those not infected with human immunodeficiency virus (HIV) (adjusted OR, 2.19; 95% Cl, 1.26-3.47). Forty cases of ESLD were observed throughout follow-up (incidence, 3.1 per 1000 person-years). In a multivariate model, risk of ESLD was higher for persons aged 38 years or older at enrollment (adjusted relative incidence, 3.67; 95% Cl, 1.96-6.88) and who reported ingestion of more than 260 g of alcohol per week (adjusted relative incidence, 3.60; 95% Cl, 1.73-7.52). Of 210 patients without ESLD randomly selected for biopsy, only 2 had cirrhosis. Conclusions: Our results indicate that although HCV infection can be self-limited or associated with ESLD, the majority of adults have persistent viremia without clinically demonstrable liver disease. Further research is needed to explain the less frequent clearance of HCV infection among black persons and to improve utilization of treatment for those infected in the context of injection drug use.

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