TY - JOUR
T1 - The Natural Flavonoid Pinocembrin
T2 - Molecular Targets and Potential Therapeutic Applications
AU - Lan, Xi
AU - Wang, Wenzhu
AU - Li, Qiang
AU - Wang, Jian
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.
AB - Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.
KW - Neuroinflammation
KW - Neuroprotection
KW - Pinocembrin
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84959383152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959383152&partnerID=8YFLogxK
U2 - 10.1007/s12035-015-9125-2
DO - 10.1007/s12035-015-9125-2
M3 - Review article
C2 - 25744566
AN - SCOPUS:84959383152
SN - 0893-7648
VL - 53
SP - 1794
EP - 1801
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 3
ER -