The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications

Xi Lan, Wenzhu Wang, Qiang Li, Jian Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.

Original languageEnglish (US)
Pages (from-to)1794-1801
Number of pages8
JournalMolecular Neurobiology
Volume53
Issue number3
DOIs
StatePublished - Apr 1 2016

Keywords

  • Neuroinflammation
  • Neuroprotection
  • Pinocembrin
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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