The natural course of schizophrenia: A review of first-admission studies

Ranganathan Ram, Evelyn J. Bromet, William W Eaton, Carlos Pato, Joseph E. Schwartz

Research output: Contribution to journalArticle

Abstract

In this article, research on the natural course of illness among first-admission schizophrenic patients is reviewed from an epidemiological perspective. Three types of studies are considered: statistical reports dating primarily from the preneuroleptic era; long-term followback studies; and more recent prospectively designed cohort studies. Although relatively more first-admission patients have a positive course than do multiple admissions patients, the findings confirm the substantial heterogeneity in course and outcome. Methodological improvements in first-admission research are suggested, including separating the analyses of first-episode patients from those with past psychotic experiences; employing longitudinal methods for deriving diagnosis; including patients with drug and alcohol problems where appropriate; enlarging the samples either by multisite or multicenter collaborations or by pooling data across studies; and obtaining better data on treatment experiences in naturalistic research.

Original languageEnglish (US)
Pages (from-to)185-207
Number of pages23
JournalSchizophrenia Bulletin
Volume18
Issue number2
DOIs
StatePublished - 1992

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schizophrenia
Patient Admission
Schizophrenia
Cohort Study
Pooling
Alcohol
Research
Drugs
Meta-Analysis
Alcohols
Cohort Studies
dating
drugs
alcohols
Pharmaceutical Preparations
Review
Experience
Admission
expansion
Therapeutics

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Radiation
  • Radiological and Ultrasound Technology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

The natural course of schizophrenia : A review of first-admission studies. / Ram, Ranganathan; Bromet, Evelyn J.; Eaton, William W; Pato, Carlos; Schwartz, Joseph E.

In: Schizophrenia Bulletin, Vol. 18, No. 2, 1992, p. 185-207.

Research output: Contribution to journalArticle

Ram, Ranganathan ; Bromet, Evelyn J. ; Eaton, William W ; Pato, Carlos ; Schwartz, Joseph E. / The natural course of schizophrenia : A review of first-admission studies. In: Schizophrenia Bulletin. 1992 ; Vol. 18, No. 2. pp. 185-207.
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