The native-state ensemble of proteins provides clues for folding, misfolding and function

Nunilo Cremades, Javier Sancho, Ernesto Freire

Research output: Contribution to journalShort surveypeer-review

Abstract

The predominant equilibrium in proteins is not between native and unfolded states, it is between the native and multiple partially unfolded forms. Some of these partially unfolded forms can be energetically close to the native state and, therefore, have the potential to become appreciably populated. This could have an important role in protein function or misfolding diseases. The recent identification and characterization of the partially unfolded forms of apoflavodoxin furthers our understanding of their formation.

Original languageEnglish (US)
Pages (from-to)494-496
Number of pages3
JournalTrends in biochemical sciences
Volume31
Issue number9
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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