The myocardium of fetuses with endocardial fibroelastosis contains fewer B and T lymphocytes than normal control myocardium

Nisha M. Fernandes, Glenn P. Taylor, Cedric Manlhiot, Brian W. McCrindle, Michael Ho, Steven E.S. Miner, Adelle Atkinson, Edgar T. Jaeggi, Lynne E. Nield

Research output: Contribution to journalArticlepeer-review

Abstract

The observation that endocardial fibroelastosis (EFE) can result from an immune response to maternal autoantibody deposition in the fetal myocardium raises the possibility that the fetal immune system may contribute to the pathogenesis of idiopathic EFE and dilated cardiomyopathy (DCM). This study sought to characterize myocardial immune cell presence in fetuses and neonates with idiopathic EFE + DCM, in those with EFE + structural heart disease, and in normal control subjects. Paraffin tissue sections from fetuses identified from the pathology database were stained for B cell, T cell, macrophage, and general hematopoietic cell surface markers. Of the 14 fetuses included in the study, 5 had EFE + DCM, 4 had EFE + structural heart disease, and 5 were normal control fetuses. The EFE + DCM group had fewer B cells than the control group (0.15 vs. 0.44 cells/mm 2; p = 0.005). The EFE + heart disease group had both fewer B cells (0.18 vs. 0.44 cells/mm 2; p = 0.08) and T cells (0.29 vs. 0.80 cells/mm 2; p = 0.04) than the control group. The CD4/CD8 ratio was similar in the EFE + DCM and EFE + heart disease groups (1.0 vs. 0.9; p = 0.17) but higher in the EFE + DCM group than in the control group (0.9 vs. 0.3; p = 0.03). The myocardium of fetuses with EFE contains fewer B and T lymphocytes than normal control fetuses.

Original languageEnglish (US)
Pages (from-to)1088-1095
Number of pages8
JournalPediatric Cardiology
Volume32
Issue number8
DOIs
StatePublished - Dec 2011
Externally publishedYes

Keywords

  • Dilated cardiomyopathy
  • Endocardial fibroelastosis
  • Immune cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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