The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family

S. Comu, W. Weng, S. Olinsky, P. Ishwad, Z. Mi, J. Hempel, S. Watkins, C. F. Lagenaur, V. Narayanan

Research output: Contribution to journalArticle

Abstract

P84 is a neuronal membrane glycoprotein that promotes the attachment and neurite outgrowth of cultured murine cerebellar cells. The heterophilic adhesive properties of P84 and its localization at sites of synaptogenesis suggest that it may be involved in regulation of synapse formation or maintenance. P84 is expressed in subsets of neurons throughout the CNS. By cloning the cDNA encoding murine P84, we have discovered that this molecule is a member of a family of phosphatase-binding proteins and is identical to the murine SHPS-1 cDNA. Here we report the cloning of two alternatively spliced forms of P84 and describe its localization within the CNS by in situ hybridization.

Original languageEnglish (US)
Pages (from-to)8702-8710
Number of pages9
JournalJournal of Neuroscience
Volume17
Issue number22
StatePublished - Nov 20 1997

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Keywords

  • Neural adhesion molecule
  • Neurite growth
  • P84
  • Phosphatase binding protein
  • Protein tyrosine phosphatase
  • SHPS-1
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Comu, S., Weng, W., Olinsky, S., Ishwad, P., Mi, Z., Hempel, J., Watkins, S., Lagenaur, C. F., & Narayanan, V. (1997). The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. Journal of Neuroscience, 17(22), 8702-8710.