The multistep nature of cancer

Research output: Contribution to journalArticle

Abstract

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalTrends in Genetics
Volume9
Issue number4
DOIs
StatePublished - 1993

Fingerprint

Mutation
Neoplasms
Inborn Genetic Diseases

ASJC Scopus subject areas

  • Genetics

Cite this

The multistep nature of cancer. / Vogelstein, Bert; Kinzler, Kenneth W.

In: Trends in Genetics, Vol. 9, No. 4, 1993, p. 138-141.

Research output: Contribution to journalArticle

@article{3971ff538f4c421d8203310ee60f6eaa,
title = "The multistep nature of cancer",
abstract = "Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.",
author = "Bert Vogelstein and Kinzler, {Kenneth W}",
year = "1993",
doi = "10.1016/0168-9525(93)90209-Z",
language = "English (US)",
volume = "9",
pages = "138--141",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - The multistep nature of cancer

AU - Vogelstein, Bert

AU - Kinzler, Kenneth W

PY - 1993

Y1 - 1993

N2 - Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

AB - Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

UR - http://www.scopus.com/inward/record.url?scp=0027401607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027401607&partnerID=8YFLogxK

U2 - 10.1016/0168-9525(93)90209-Z

DO - 10.1016/0168-9525(93)90209-Z

M3 - Article

C2 - 8516849

AN - SCOPUS:0027401607

VL - 9

SP - 138

EP - 141

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 4

ER -