TY - JOUR
T1 - The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function
AU - Blumberg, Richard S.
AU - Van De Wal, Yvonne D.
AU - Claypool, Steven
AU - Corazza, Nadia
AU - Dickinson, Bonny
AU - Nieuwenhuis, Edward
AU - Pitman, Richard
AU - Spiekermann, Gerburg
AU - Zhu, Xiaoping
AU - Colgan, Sean
AU - Lencer, Wayne I.
PY - 2001/6
Y1 - 2001/6
N2 - The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A. B. and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including GDI, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.
AB - The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A. B. and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including GDI, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.
KW - Epithelium: Intestine
KW - Major histocompatibility complex
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U2 - 10.1080/000163501750266729
DO - 10.1080/000163501750266729
M3 - Article
C2 - 11501882
AN - SCOPUS:18044402834
SN - 0001-6357
VL - 59
SP - 139
EP - 144
JO - Acta Odontologica Scandinavica
JF - Acta Odontologica Scandinavica
IS - 3
ER -