The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function

Richard S. Blumberg, Yvonne D. Van De Wal, Steven Claypool, Nadia Corazza, Bonny Dickinson, Edward Nieuwenhuis, Richard Pitman, Gerburg Spiekermann, Xiaoping Zhu, Sean Colgan, Wayne I. Lencer

Research output: Contribution to journalArticle

Abstract

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A. B. and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including GDI, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalActa Odontologica Scandinavica
Volume59
Issue number3
DOIs
StatePublished - Jun 1 2001
Externally publishedYes

Keywords

  • Epithelium: Intestine
  • Major histocompatibility complex

ASJC Scopus subject areas

  • Dentistry(all)

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    Blumberg, R. S., Van De Wal, Y. D., Claypool, S., Corazza, N., Dickinson, B., Nieuwenhuis, E., Pitman, R., Spiekermann, G., Zhu, X., Colgan, S., & Lencer, W. I. (2001). The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function. Acta Odontologica Scandinavica, 59(3), 139-144. https://doi.org/10.1080/000163501750266729