The multidrug resistance (mdr1) gene product functions as an ATP channel

Edward H. Abraham, Adriana G. Prat, Leo Gerweck, Tara Seneveratne, Robert J. Arceci, Robert Kramer, Guido Guidotti, Horacio F. Cantiello

Research output: Contribution to journalArticle

Abstract

The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.

Original languageEnglish (US)
Pages (from-to)312-316
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number1
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • General

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    Abraham, E. H., Prat, A. G., Gerweck, L., Seneveratne, T., Arceci, R. J., Kramer, R., Guidotti, G., & Cantiello, H. F. (1993). The multidrug resistance (mdr1) gene product functions as an ATP channel. Proceedings of the National Academy of Sciences of the United States of America, 90(1), 312-316. https://doi.org/10.1073/pnas.90.1.312