TY - JOUR
T1 - The multidrug resistance (mdr1) gene product functions as an ATP channel
AU - Abraham, Edward H.
AU - Prat, Adriana G.
AU - Gerweck, Leo
AU - Seneveratne, Tara
AU - Arceci, Robert J.
AU - Kramer, Robert
AU - Guidotti, Guido
AU - Cantiello, Horacio F.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.
AB - The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.
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U2 - 10.1073/pnas.90.1.312
DO - 10.1073/pnas.90.1.312
M3 - Article
C2 - 7678345
AN - SCOPUS:0027475309
SN - 0027-8424
VL - 90
SP - 312
EP - 316
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 1
ER -