The Multicenter Morphometric Mammary Carcinoma Project (MMMCP): A Nationwide Prospective Study on Reproducibility and Prognostic Power of Routine Quantitative Assessments in the Netherlands

J. P.A. Baak, Paulus Joannes van Diest, A. Th Ariens, M. W.P.M. van Beek, S. M. Bellot, J. Fijnheer, L. H.M. van Gorp, W. S. Kwee, J. Los, H. C. Peterse, H. M. Ruitenberg, R. F.M. Schapers, M. E.I. Schipper, J. G. Somsen

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The Multicenter Morphometric Mammary Carcinoma Project (MMMCP) has been set up to investigate prospectively the prognostic value and reproducibility of routine assessments of the morphometric Multivariate Prognostic Index (MPI) and other quantitative parameters in comparison with classical prognosticators and steroid receptors in breast cancer patients. In this project, 34 hospitals participate, divided over six geographically different regions. Of each patient entering in the study, multiple clinical and classical pathological parameters. (including tumor size and lymph node status) as well as several quantitative parameters such as mean nuclear area, DNA index and mitotic activity index will be evaluated. Of all patients, the MPI will be assessed with tumour size, lymph node status and mitotic activity index. The quantitative assessments are performed in all consecutive breast cancers which enter the participating pathology laboratories, and all measurements are controlled in Amsterdam. The patient intake time will be from January 1, 1988 until January 1, 1990. It is expected that 3 000 patients will enter in this study. Follow up data will be gathered up to 10 years. However, two to five years after the initiation of the Project, a first evaluation of the reproducibility and prognostic significance of routine MPI and other assessments in breast cancer patients will be possible. A detailed description of this project is given.

Original languageEnglish (US)
Pages (from-to)664-670
Number of pages7
JournalPathology Research and Practice
Volume185
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Breast cancer
  • Morphometry
  • Prognosis
  • Reproducibility

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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