Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouseAqp1,the structural gene was isolated and a restriction map was constructed. The 13-kbAqp1gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 bp 5′ to the translation initiation site and 20 bp 3′ from a TATAA consensus sequence.Aqp1was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, whereAQP1had previously been localized. These studies have revealed marked structural similarities between the mouseAqp1and the humanAQP1genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.
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