The MouseAquaporin-1Gene

Chulso Moon, John B. Williams, Gregory M. Preston, Neal G. Copeland, Debra J. Gilbert, Daniel Nathans, Nancy A. Jenkins, Peter C Agre

Research output: Contribution to journalArticle

Abstract

Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouseAqp1,the structural gene was isolated and a restriction map was constructed. The 13-kbAqp1gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 bp 5′ to the translation initiation site and 20 bp 3′ from a TATAA consensus sequence.Aqp1was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, whereAQP1had previously been localized. These studies have revealed marked structural similarities between the mouseAqp1and the humanAQP1genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalGenomics
Volume30
Issue number2
DOIs
Publication statusPublished - Nov 1995

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ASJC Scopus subject areas

  • Genetics

Cite this

Moon, C., Williams, J. B., Preston, G. M., Copeland, N. G., Gilbert, D. J., Nathans, D., ... Agre, P. C. (1995). The MouseAquaporin-1Gene. Genomics, 30(2), 354-357. https://doi.org/10.1006/geno.1995.0029