Nitrogen dioxide inhalation exposures are used to evaluate the biological mechanisms and dose-response of animals to known concentrations of nitrogen dioxide. This paper describes generation techniques which have been evaluated and the final method using a Teflon bag-pump system chosen for safety, reproducibility, and stability. Also included are the problems and solutions of using a chemiluminescent NO2 analyzer for monitoring chamber concentrations. The problems typically are related to stability, and the recommended solution is to use an NO2 permeation system for calibration.
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health