The molecular pathogenesis of cholestasis in sepsis

Harjit K. Bhogal, Arun J. Sanyal

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Sepsis-induced cholestasis is a complication of infection. Infections cause systemic and intrahepatic increase in proinflammatory cytokines which result in impaired bile flow ie. cholestasis. Several other mediators of impairment in bile flow have been identified under conditions of sepsis such as increased nitric oxide production and decreased aquaporin channels. The development of cholestasis may also further worsen inflammation. The molecular basis of normal bile flow and mechanisms of impairment in sepsis are discussed.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number1
StatePublished - Jan 1 2013
Externally publishedYes


  • Acute of chronic liver failure
  • Acute phase reaction
  • Bacterial translocation
  • Bile acids
  • Bilirubin
  • Bilirubinostasis
  • Cholestasis
  • Cirrhosis
  • Review
  • Sepsis
  • Tumor necrosis factor-á

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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