The molecular pathogenesis of cholestasis in sepsis

Harjit K. Bhogal, Arun J. Sanyal

Research output: Contribution to journalArticle

Abstract

Sepsis-induced cholestasis is a complication of infection. Infections cause systemic and intrahepatic increase in proinflammatory cytokines which result in impaired bile flow ie. cholestasis. Several other mediators of impairment in bile flow have been identified under conditions of sepsis such as increased nitric oxide production and decreased aquaporin channels. The development of cholestasis may also further worsen inflammation. The molecular basis of normal bile flow and mechanisms of impairment in sepsis are discussed.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number1
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Aquaporins
Cholestasis
Bile
Sepsis
Nitric Oxide
Cytokines
Infection
Inflammation

Keywords

  • Acute of chronic liver failure
  • Acute phase reaction
  • Bacterial translocation
  • Bile acids
  • Bilirubin
  • Bilirubinostasis
  • Cholestasis
  • Cirrhosis
  • Review
  • Sepsis
  • Tumor necrosis factor-á

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Bhogal, H. K., & Sanyal, A. J. (2013). The molecular pathogenesis of cholestasis in sepsis. Frontiers in Bioscience - Elite, 5 E(1), 87-96.

The molecular pathogenesis of cholestasis in sepsis. / Bhogal, Harjit K.; Sanyal, Arun J.

In: Frontiers in Bioscience - Elite, Vol. 5 E, No. 1, 01.01.2013, p. 87-96.

Research output: Contribution to journalArticle

Bhogal, HK & Sanyal, AJ 2013, 'The molecular pathogenesis of cholestasis in sepsis', Frontiers in Bioscience - Elite, vol. 5 E, no. 1, pp. 87-96.
Bhogal, Harjit K. ; Sanyal, Arun J. / The molecular pathogenesis of cholestasis in sepsis. In: Frontiers in Bioscience - Elite. 2013 ; Vol. 5 E, No. 1. pp. 87-96.
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