The molecular mechanics of eukaryotic translation

Lee D. Kapp, Jon R. Lorsch

Research output: Contribution to journalReview articlepeer-review

383 Scopus citations


Great advances have been made in the past three decades in understanding the molecular mechanics underlying protein synthesis in bacteria, but our understanding of the corresponding events in eukaryotic organisms is only beginning to catch up. In this review we describe the current state of our knowledge and ignorance of the molecular mechanics underlying eukaryotic translation. We discuss the mechanisms conserved across the three kingdoms of life as well as the important divergences that have taken place in the pathway.

Original languageEnglish (US)
Pages (from-to)657-704
Number of pages48
JournalAnnual review of biochemistry
StatePublished - Aug 20 2004


  • Elongation
  • Initiation
  • Protein synthesis
  • Recycling
  • Termination

ASJC Scopus subject areas

  • Biochemistry


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