The molecular events in heavy chain class-switching.

Paul B Rothman, S. C. Li, F. W. Alt

Research output: Contribution to journalArticle

Abstract

Heavy chain class-switching is the process by which B lymphoid cells change the constant region of the immunoglobulin heavy chain they produce. Class-switching is most commonly accomplished by recombinationldeletion between switch recombination regions that lie upstream of each germline heavy chain constant region gene. Recent studies support a model that recombination to specific switch regions is directed by modulation of the accessibility of these regions to a common class-switch recombination system. T cell lymphokines seem to be able to alter the accessibility of different heavy chain constant region loci, and thereby direct the specificity of class-switch recombination in B cells.

Original languageEnglish (US)
Pages (from-to)65-77
Number of pages13
JournalSeminars in Immunology
Volume1
Issue number1
StatePublished - Sep 1989
Externally publishedYes

Fingerprint

Immunoglobulin Class Switching
Genetic Recombination
Immunoglobulin Heavy Chains
Lymphokines
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

The molecular events in heavy chain class-switching. / Rothman, Paul B; Li, S. C.; Alt, F. W.

In: Seminars in Immunology, Vol. 1, No. 1, 09.1989, p. 65-77.

Research output: Contribution to journalArticle

Rothman, Paul B ; Li, S. C. ; Alt, F. W. / The molecular events in heavy chain class-switching. In: Seminars in Immunology. 1989 ; Vol. 1, No. 1. pp. 65-77.
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