The molecular basis of hypopituitarism

Sally Radovick, Laurie E. Cohen, Fredric E. Wondisford

Research output: Contribution to journalArticle

Abstract

Pit-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. My laboratory and others have recently described several patients with combined pituitary hormone deficiency (CPHD) due to point mutations in the pit-1 gene. In addition to pit-1, other activation of the GH gene. The Prl gene is regulated synergistically by pit-1 and the estrogen receptor. Finally, the pit-1 gene itself is regulated by an nuclear factors appear to be necessary for full expression of pituitary genes. A zinc finger transcription factor, Zn-15, is responsible with pit-1 for synergistic enhancer element located > 10 kb upstream of the transcriptional start. This element contains several pit-1 DNA binding sites and retinoic acid response elements (RAREs). On one of these elements, pit-1 and RAR interact functionally to mediate a synergistic response to RA. Recent data from our laboratory suggests that RA induction of the pit-1 gene can be impaired by pit-1 gene mutations. Study of pit-1 mutations and their diverse pathophysiological mechanisms should increase our understanding of anterior pituitary gland development and gene regulation in normal and disease states.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalHormone Research
Volume49
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 1998
Externally publishedYes

Fingerprint

Hypopituitarism
Genes
Transcription Factors
Mutation
Anterior Pituitary Gland
Pituitary Hormones
Zinc Fingers
Response Elements
Tretinoin
Point Mutation
Estrogen Receptors
Transcriptional Activation
Mammals
Binding Sites
Gene Expression
DNA

Keywords

  • Combined pituitary hormone deficiency
  • Gene expression
  • Gene mutations
  • Gene regulation
  • Hypopituitarism
  • pit-1
  • Pituitary development
  • Retinoic acid
  • Zn-15

ASJC Scopus subject areas

  • Endocrinology

Cite this

Radovick, S., Cohen, L. E., & Wondisford, F. E. (1998). The molecular basis of hypopituitarism. Hormone Research, 49(SUPPL. 1), 30-36. https://doi.org/10.1159/000053065

The molecular basis of hypopituitarism. / Radovick, Sally; Cohen, Laurie E.; Wondisford, Fredric E.

In: Hormone Research, Vol. 49, No. SUPPL. 1, 03.1998, p. 30-36.

Research output: Contribution to journalArticle

Radovick, S, Cohen, LE & Wondisford, FE 1998, 'The molecular basis of hypopituitarism', Hormone Research, vol. 49, no. SUPPL. 1, pp. 30-36. https://doi.org/10.1159/000053065
Radovick S, Cohen LE, Wondisford FE. The molecular basis of hypopituitarism. Hormone Research. 1998 Mar;49(SUPPL. 1):30-36. https://doi.org/10.1159/000053065
Radovick, Sally ; Cohen, Laurie E. ; Wondisford, Fredric E. / The molecular basis of hypopituitarism. In: Hormone Research. 1998 ; Vol. 49, No. SUPPL. 1. pp. 30-36.
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