DNA from individuals heterozygous for the extended α-chain variant Hb Grady were studied by gene counting and restriction enzyme analysis. Neither method indicated the presence of an extra (fifth) α gene, which argues that if this variant arose by unequal crossing over, the event most likely involved mispairing between alleles rather than between the separate α1 and α2 loci.
|Original language||English (US)|
|Number of pages||5|
|Journal||American Journal of Human Genetics|
|Publication status||Published - 1981|
ASJC Scopus subject areas