The molecular basis of hemoglobin Grady

A. F. Scott, J. A. Phillips, K. E. Young, H. H. Kazazian, K. D. Smith, S. Charache, J. B. Clegg

Research output: Contribution to journalArticlepeer-review


DNA from individuals heterozygous for the extended α-chain variant Hb Grady were studied by gene counting and restriction enzyme analysis. Neither method indicated the presence of an extra (fifth) α gene, which argues that if this variant arose by unequal crossing over, the event most likely involved mispairing between alleles rather than between the separate α1 and α2 loci.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalAmerican journal of human genetics
Issue number1
StatePublished - May 1 1981

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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