The molecular basis of hemoglobin Grady

A. F. Scott, J. A. Phillips, K. E. Young, H. H. Kazazian, K. D. Smith, S. Charache, J. B. Clegg

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Abstract

DNA from individuals heterozygous for the extended α-chain variant Hb Grady were studied by gene counting and restriction enzyme analysis. Neither method indicated the presence of an extra (fifth) α gene, which argues that if this variant arose by unequal crossing over, the event most likely involved mispairing between alleles rather than between the separate α1 and α2 loci.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalAmerican Journal of Human Genetics
Volume33
Issue number1
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Genetics

Cite this

Scott, A. F., Phillips, J. A., Young, K. E., Kazazian, H. H., Smith, K. D., Charache, S., & Clegg, J. B. (1981). The molecular basis of hemoglobin Grady. American Journal of Human Genetics, 33(1), 129-133.