The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus

R. F. Souza, Stephen Meltzer

Research output: Contribution to journalArticle

Abstract

Barrett's esophagus carries an increased risk for the development of esophageal adenocarcinoma. A wide variety of biologic events play a role in the initiation and progression of Barrett's esophagus to malignancy. Understanding Balrett's-associated neoplasia at the molecular level could generate markers predictive of malignant change. The next several years promise many discoveries of not only these molecular markers of tumorigenesis, but also their clinical application as means of preventing and treating the deadly complications of Barrett's esophagus.

Original languageEnglish (US)
Pages (from-to)583-597
Number of pages15
JournalGastroenterology Clinics of North America
Volume26
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Barrett Esophagus
Esophagus
Carcinogenesis
Neoplasms
Adenocarcinoma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus. / Souza, R. F.; Meltzer, Stephen.

In: Gastroenterology Clinics of North America, Vol. 26, No. 3, 1997, p. 583-597.

Research output: Contribution to journalArticle

@article{8244488d2ba74ec1aaf2e82aaa663bf0,
title = "The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus",
abstract = "Barrett's esophagus carries an increased risk for the development of esophageal adenocarcinoma. A wide variety of biologic events play a role in the initiation and progression of Barrett's esophagus to malignancy. Understanding Balrett's-associated neoplasia at the molecular level could generate markers predictive of malignant change. The next several years promise many discoveries of not only these molecular markers of tumorigenesis, but also their clinical application as means of preventing and treating the deadly complications of Barrett's esophagus.",
author = "Souza, {R. F.} and Stephen Meltzer",
year = "1997",
doi = "10.1016/S0889-8553(05)70315-0",
language = "English (US)",
volume = "26",
pages = "583--597",
journal = "Gastroenterology Clinics of North America",
issn = "0889-8553",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus

AU - Souza, R. F.

AU - Meltzer, Stephen

PY - 1997

Y1 - 1997

N2 - Barrett's esophagus carries an increased risk for the development of esophageal adenocarcinoma. A wide variety of biologic events play a role in the initiation and progression of Barrett's esophagus to malignancy. Understanding Balrett's-associated neoplasia at the molecular level could generate markers predictive of malignant change. The next several years promise many discoveries of not only these molecular markers of tumorigenesis, but also their clinical application as means of preventing and treating the deadly complications of Barrett's esophagus.

AB - Barrett's esophagus carries an increased risk for the development of esophageal adenocarcinoma. A wide variety of biologic events play a role in the initiation and progression of Barrett's esophagus to malignancy. Understanding Balrett's-associated neoplasia at the molecular level could generate markers predictive of malignant change. The next several years promise many discoveries of not only these molecular markers of tumorigenesis, but also their clinical application as means of preventing and treating the deadly complications of Barrett's esophagus.

UR - http://www.scopus.com/inward/record.url?scp=0030666367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030666367&partnerID=8YFLogxK

U2 - 10.1016/S0889-8553(05)70315-0

DO - 10.1016/S0889-8553(05)70315-0

M3 - Article

C2 - 9309406

AN - SCOPUS:0030666367

VL - 26

SP - 583

EP - 597

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

SN - 0889-8553

IS - 3

ER -