The Molecular and Clinical Landscape of Pancreatic Neuroendocrine Tumors

Bhavina D.O. Batukbhai, Ana De Jesus-Acosta

Research output: Contribution to journalReview articlepeer-review


Pancreatic neuroendocrine tumors are rare tumors of the pancreas originating from the islets of the Langerhans. These tumors comprise 1% to 3% of all newly diagnosed pancreatic cancers every year and have a unique heterogeneity in clinical presentation. Whole-genome sequencing has led to an increased understanding of the molecular biology of these tumors. In this review, we will summarize the current knowledge of the signaling pathways involved in the tumorigenesis of pancreatic neuroendocrine tumors as well as the major studies targeting these pathways at preclinical and clinical levels.

Original languageEnglish (US)
Pages (from-to)9-21
Number of pages13
Issue number1
StatePublished - Jan 1 2019


  • checkpoints
  • molecular biology
  • pancreatic neuroendocrine tumor
  • panNET
  • signaling pathways
  • tumorigenesis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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