The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

Medicine & Life Sciences

• 2,4-Dinitrophenol 100%
• Cyclic AMP Response Element-Binding Protein 87%
• TOR Serine-Threonine Kinases 77%
• Up-Regulation 50%
• Brain 34%
• Neuronal Plasticity 20%
• Energy Metabolism 19%
• Uncoupling Agents 18%
• Fasting 17%
• Autophagy 15%
• Cerebral Cortex 14%
• Insulin 14%
• Neurons 9%
• Proton Ionophores 9%
• Tuberous Sclerosis 2 9%
• Psychological Inhibition 8%
• Learning 7%
• Memory 7%
• Memory and Learning Tests 7%
• Cellular Reprogramming 6%
• Tuberous Sclerosis 6%
• Mitochondrial Membrane Potential 5%
• Brain-Derived Neurotrophic Factor 5%
• Gene Expression Profiling 5%
• Phosphatidylinositol 3-Kinases 5%
• Wounds and Injuries 5%
• Nutrients 4%
• Mitochondria 4%
• Weight Loss 4%
• Proteins 3%
• Oxidative Stress 3%
• Gene Expression 3%
• Therapeutics 1%

Chemical Compounds

• 2,4-dinitrophenol 92%
• Mammalian Cell 72%
• Protein 28%
• Insulin Derivative 28%
• Uncoupling Agent 23%
• Plastic Property 16%
• Proton Ionophore 12%
• Membrane Potential 7%
• Nutrient 7%
• Oxidative Stress 6%
• Energy 6%
• Pharmacological Metabolism 5%
• Application 4%