The Mitochondrial Basis of Aging

Nuo Sun, Richard J. Youle, Toren Finkel

Research output: Contribution to journalArticlepeer-review


A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and the age-dependent decline in stem cell activity. Signaling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewed, with particular emphasis placed on how these pathways might, in turn, regulate longevity. Taken together, these observations suggest that mitochondria influence or regulate a number of key aspects of aging and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects.

Original languageEnglish (US)
Pages (from-to)654-666
Number of pages13
JournalMolecular Cell
Issue number5
StatePublished - Mar 3 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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