The minimal important difference of exercise tests in severe COPD

M. A. Puhan, D. Chandra, Z. Mosenifar, A. Ries, B. Make, Nadia Hansel, Robert A Wise, F. Sciurba

Research output: Contribution to journalArticle

Abstract

Our aim was to determine the minimal important difference (MID) for 6-min walk distance (6MWD) and maximal cycle exercise capacity (MCEC) in patients with severe chronic obstructive pulmonary disease (COPD). 1,218 patients enrolled in the National Emphysema Treatment Trial completed exercise tests before and after 4-6 weeks of pre-trial rehabilitation, and 6 months after randomisation to surgery or medical care. The St George's Respiratory Questionnaire (domain and total scores) and University of California San Diego Shortness of Breath Questionnaire (total score) served as anchors for anchor-based MID estimates. In order to calculate distribution-based estimates, we used the standard error of measurement, Cohen's effect size and the empirical rule effect size. Anchor-based estimates for the 6MWD were 18.9 m (95% CI 18.1-20.1 m), 24.2 m (95% CI 23.4-25.4 m), 24.6 m (95% CI 23.4-25.7 m) and 26.4 m (95% CI 25.4-27.4 m), which were similar to distribution-based MID estimates of 25.7, 26.8 and 30.6 m. For MCEC, anchor-based estimates for the MID were 2.2 W (95% CI 2.0-2.4 W), 3.2 W (95% CI 3.0-3.4 W), 3.2 W (95% CI 3.0-3.4 W) and 3.3 W (95% CI 3.0-3.5 W), while distribution-based estimates were 5.3 and 5.5 W. We suggest a MID of 26±2 m for 6MWD and 4±1 W for MCEC for patients with severe COPD. Copyright

Original languageEnglish (US)
Pages (from-to)784-790
Number of pages7
JournalEuropean Respiratory Journal
Volume37
Issue number4
DOIs
StatePublished - Apr 1 2011

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Exercise Test
Chronic Obstructive Pulmonary Disease
Exercise
Emphysema
Random Allocation
Dyspnea
Rehabilitation
Surveys and Questionnaires
Therapeutics

Keywords

  • Chronic obstructive pulmonary disease
  • Chronic obstructive pulmonary disease treatment
  • Clinical trials
  • Exercise tests
  • Rehabilitation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Puhan, M. A., Chandra, D., Mosenifar, Z., Ries, A., Make, B., Hansel, N., ... Sciurba, F. (2011). The minimal important difference of exercise tests in severe COPD. European Respiratory Journal, 37(4), 784-790. https://doi.org/10.1183/09031936.00063810

The minimal important difference of exercise tests in severe COPD. / Puhan, M. A.; Chandra, D.; Mosenifar, Z.; Ries, A.; Make, B.; Hansel, Nadia; Wise, Robert A; Sciurba, F.

In: European Respiratory Journal, Vol. 37, No. 4, 01.04.2011, p. 784-790.

Research output: Contribution to journalArticle

Puhan, MA, Chandra, D, Mosenifar, Z, Ries, A, Make, B, Hansel, N, Wise, RA & Sciurba, F 2011, 'The minimal important difference of exercise tests in severe COPD', European Respiratory Journal, vol. 37, no. 4, pp. 784-790. https://doi.org/10.1183/09031936.00063810
Puhan, M. A. ; Chandra, D. ; Mosenifar, Z. ; Ries, A. ; Make, B. ; Hansel, Nadia ; Wise, Robert A ; Sciurba, F. / The minimal important difference of exercise tests in severe COPD. In: European Respiratory Journal. 2011 ; Vol. 37, No. 4. pp. 784-790.
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