The microbiome and breast cancer

a review

Jennifer Chen, Jacqueline Douglass, Vishnu Prasath, Meghan Neace, Siavash Atrchian, Masoud H. Manjili, Shervin Shokouhi, Mehran Habibi

Research output: Contribution to journalReview article

Abstract

The human microbiome plays an integral role in physiology, with most microbes considered benign or beneficial. However, some microbes are known to be detrimental to human health, including organisms linked to cancers and other diseases characterized by aberrant inflammation. Dysbiosis, a state of microbial imbalance with harmful bacteria species outcompeting benign bacteria, can lead to maladies including cancer. The microbial composition varies across body sites, with the gut, urogenital, and skin microbiomes particularly well characterized. However, the microbiome associated with normal breast tissue and breast diseases is poorly understood. Collectively, studies have shown that breast tissue has a distinct microbiome with particular species enriched in the breast tissue itself, as well as the nipple aspirate and gut bacteria of women with breast cancer. More importantly, the breast and associated microbiomes may modulate therapeutic response and serve as potential biomarkers for diagnosing and staging breast cancer.

Original languageEnglish (US)
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Microbiota
Breast Neoplasms
Breast
Bacteria
Dysbiosis
Breast Diseases
Nipples
Neoplasms
Biomarkers
Inflammation
Skin
Health

Keywords

  • Breast cancer
  • Flora
  • Gut
  • Immune response
  • Microbiome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Chen, J., Douglass, J., Prasath, V., Neace, M., Atrchian, S., Manjili, M. H., ... Habibi, M. (Accepted/In press). The microbiome and breast cancer: a review. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-019-05407-5

The microbiome and breast cancer : a review. / Chen, Jennifer; Douglass, Jacqueline; Prasath, Vishnu; Neace, Meghan; Atrchian, Siavash; Manjili, Masoud H.; Shokouhi, Shervin; Habibi, Mehran.

In: Breast Cancer Research and Treatment, 01.01.2019.

Research output: Contribution to journalReview article

Chen, J, Douglass, J, Prasath, V, Neace, M, Atrchian, S, Manjili, MH, Shokouhi, S & Habibi, M 2019, 'The microbiome and breast cancer: a review', Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-019-05407-5
Chen J, Douglass J, Prasath V, Neace M, Atrchian S, Manjili MH et al. The microbiome and breast cancer: a review. Breast Cancer Research and Treatment. 2019 Jan 1. https://doi.org/10.1007/s10549-019-05407-5
Chen, Jennifer ; Douglass, Jacqueline ; Prasath, Vishnu ; Neace, Meghan ; Atrchian, Siavash ; Manjili, Masoud H. ; Shokouhi, Shervin ; Habibi, Mehran. / The microbiome and breast cancer : a review. In: Breast Cancer Research and Treatment. 2019.
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