The microbiome and autoimmune disease: Report from a Noel R. Rose Colloquium

Jobert G. Barin, Lawrence D. Tobias, Daniel A. Peterson

Research output: Contribution to journalArticlepeer-review

Abstract

Although the mechanisms by which the human microbiome influences the onset and progression of autoimmune diseases remain to be determined, established animal models of autoimmune diseases indicate that local and systemic bidirectional interactions with the microbiome play a signaling or promoting role through the immune system. Whether alterations in the microbiome are a pathogenic cause or simply an effect of inflammation and autoimmune disease remains an essential question to be addressed in disease-specific research, as well as whether particular conditions of the microbiome promote health or promote disease. Future research in this area needs to account for sex differences in microbiome composition because autoimmune diseases disproportionately affect women. Probiotic and other treatments that manipulate assemblage of the microbiome may offer methods of preventing or mitigating the effects of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalClinical Immunology
Volume159
Issue number2
DOIs
StatePublished - Oct 20 2014

Keywords

  • Autoimmune disease
  • Autoimmunity
  • Colloquium
  • Microbiome
  • Mucosal immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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