The microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study

H. Erdem, D. Ozturk-Engin, N. Elaldi, S. Gulsun, G. Sengoz, A. Crisan, I. S. Johansen, A. Inan, M. Nechifor, A. Al-Mahdawi, R. Civljak, M. Ozguler, B. Savic, N. Ceran, B. Cacopardo, A. S. Inal, M. Namiduru, S. Dayan, U. Kayabas, E. ParlakA. Khalifa, E. Kursun, O. R. Sipahi, M. Yemisen, A. Akbulut, M. Bitirgen, O. Dulovic, B. Kandemir, C. Luca, M. Parlak, J. P. Stahl, F. Pehlivanoglu, S. Simeon, A. Ulu-Kilic, K. Yasar, G. Yilmaz, E. Yilmaz, B. Beovic, M. Catroux, B. Lakatos, M. Sunbul, O. Oncul, S. Alabay, E. Sahin-Horasan, S. Kose, G. Shehata, K. Andre, A. Alp, G. Ćosić, H. Cem Gul, A. Karakas, S. Chadapaud, Y. Hansmann, A. Harxhi, V. Kirova, I. Masse-Chabredier, S. Oncu, A. Sener, R. Tekin, O. Deveci, O. Karabay, C. Agalar

Research output: Contribution to journalArticle

Abstract

We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-γ release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p 

Original languageEnglish (US)
Pages (from-to)O600-O608
JournalClinical Microbiology and Infection
Volume20
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Meningeal Tuberculosis
Cerebrospinal Fluid
Albania
Syria
Slovenia
Serbia
Romania
Iraq
Polymerase Chain Reaction
Croatia
Adenosine Deaminase
Hungary
Egypt
Denmark
Turkey
Meningitis
Gold
Interferons
Italy
France

Keywords

  • PCR
  • Culture
  • Diagnosis
  • Meningitis
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

Erdem, H., Ozturk-Engin, D., Elaldi, N., Gulsun, S., Sengoz, G., Crisan, A., ... Agalar, C. (2014). The microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study. Clinical Microbiology and Infection, 20(10), O600-O608. https://doi.org/10.1111/1469-0691.12478

The microbiological diagnosis of tuberculous meningitis : Results of Haydarpasa-1 study. / Erdem, H.; Ozturk-Engin, D.; Elaldi, N.; Gulsun, S.; Sengoz, G.; Crisan, A.; Johansen, I. S.; Inan, A.; Nechifor, M.; Al-Mahdawi, A.; Civljak, R.; Ozguler, M.; Savic, B.; Ceran, N.; Cacopardo, B.; Inal, A. S.; Namiduru, M.; Dayan, S.; Kayabas, U.; Parlak, E.; Khalifa, A.; Kursun, E.; Sipahi, O. R.; Yemisen, M.; Akbulut, A.; Bitirgen, M.; Dulovic, O.; Kandemir, B.; Luca, C.; Parlak, M.; Stahl, J. P.; Pehlivanoglu, F.; Simeon, S.; Ulu-Kilic, A.; Yasar, K.; Yilmaz, G.; Yilmaz, E.; Beovic, B.; Catroux, M.; Lakatos, B.; Sunbul, M.; Oncul, O.; Alabay, S.; Sahin-Horasan, E.; Kose, S.; Shehata, G.; Andre, K.; Alp, A.; Ćosić, G.; Cem Gul, H.; Karakas, A.; Chadapaud, S.; Hansmann, Y.; Harxhi, A.; Kirova, V.; Masse-Chabredier, I.; Oncu, S.; Sener, A.; Tekin, R.; Deveci, O.; Karabay, O.; Agalar, C.

In: Clinical Microbiology and Infection, Vol. 20, No. 10, 01.10.2014, p. O600-O608.

Research output: Contribution to journalArticle

Erdem, H, Ozturk-Engin, D, Elaldi, N, Gulsun, S, Sengoz, G, Crisan, A, Johansen, IS, Inan, A, Nechifor, M, Al-Mahdawi, A, Civljak, R, Ozguler, M, Savic, B, Ceran, N, Cacopardo, B, Inal, AS, Namiduru, M, Dayan, S, Kayabas, U, Parlak, E, Khalifa, A, Kursun, E, Sipahi, OR, Yemisen, M, Akbulut, A, Bitirgen, M, Dulovic, O, Kandemir, B, Luca, C, Parlak, M, Stahl, JP, Pehlivanoglu, F, Simeon, S, Ulu-Kilic, A, Yasar, K, Yilmaz, G, Yilmaz, E, Beovic, B, Catroux, M, Lakatos, B, Sunbul, M, Oncul, O, Alabay, S, Sahin-Horasan, E, Kose, S, Shehata, G, Andre, K, Alp, A, Ćosić, G, Cem Gul, H, Karakas, A, Chadapaud, S, Hansmann, Y, Harxhi, A, Kirova, V, Masse-Chabredier, I, Oncu, S, Sener, A, Tekin, R, Deveci, O, Karabay, O & Agalar, C 2014, 'The microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study', Clinical Microbiology and Infection, vol. 20, no. 10, pp. O600-O608. https://doi.org/10.1111/1469-0691.12478
Erdem, H. ; Ozturk-Engin, D. ; Elaldi, N. ; Gulsun, S. ; Sengoz, G. ; Crisan, A. ; Johansen, I. S. ; Inan, A. ; Nechifor, M. ; Al-Mahdawi, A. ; Civljak, R. ; Ozguler, M. ; Savic, B. ; Ceran, N. ; Cacopardo, B. ; Inal, A. S. ; Namiduru, M. ; Dayan, S. ; Kayabas, U. ; Parlak, E. ; Khalifa, A. ; Kursun, E. ; Sipahi, O. R. ; Yemisen, M. ; Akbulut, A. ; Bitirgen, M. ; Dulovic, O. ; Kandemir, B. ; Luca, C. ; Parlak, M. ; Stahl, J. P. ; Pehlivanoglu, F. ; Simeon, S. ; Ulu-Kilic, A. ; Yasar, K. ; Yilmaz, G. ; Yilmaz, E. ; Beovic, B. ; Catroux, M. ; Lakatos, B. ; Sunbul, M. ; Oncul, O. ; Alabay, S. ; Sahin-Horasan, E. ; Kose, S. ; Shehata, G. ; Andre, K. ; Alp, A. ; Ćosić, G. ; Cem Gul, H. ; Karakas, A. ; Chadapaud, S. ; Hansmann, Y. ; Harxhi, A. ; Kirova, V. ; Masse-Chabredier, I. ; Oncu, S. ; Sener, A. ; Tekin, R. ; Deveci, O. ; Karabay, O. ; Agalar, C. / The microbiological diagnosis of tuberculous meningitis : Results of Haydarpasa-1 study. In: Clinical Microbiology and Infection. 2014 ; Vol. 20, No. 10. pp. O600-O608.
@article{265496076d1b4f78b421430099da62ac,
title = "The microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study",
abstract = "We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-γ release assay (Quantiferon TB gold in tube) 90.2{\%}, automated culture systems (ACS) 81.8{\%}, L{\"o}wenstein Jensen medium (L-J) 72.7{\%}, adenosine deaminase (ADA) 29.9{\%} and EZNs 27.3{\%}. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p ",
keywords = "PCR, Culture, Diagnosis, Meningitis, Tuberculosis",
author = "H. Erdem and D. Ozturk-Engin and N. Elaldi and S. Gulsun and G. Sengoz and A. Crisan and Johansen, {I. S.} and A. Inan and M. Nechifor and A. Al-Mahdawi and R. Civljak and M. Ozguler and B. Savic and N. Ceran and B. Cacopardo and Inal, {A. S.} and M. Namiduru and S. Dayan and U. Kayabas and E. Parlak and A. Khalifa and E. Kursun and Sipahi, {O. R.} and M. Yemisen and A. Akbulut and M. Bitirgen and O. Dulovic and B. Kandemir and C. Luca and M. Parlak and Stahl, {J. P.} and F. Pehlivanoglu and S. Simeon and A. Ulu-Kilic and K. Yasar and G. Yilmaz and E. Yilmaz and B. Beovic and M. Catroux and B. Lakatos and M. Sunbul and O. Oncul and S. Alabay and E. Sahin-Horasan and S. Kose and G. Shehata and K. Andre and A. Alp and G. Ćosić and {Cem Gul}, H. and A. Karakas and S. Chadapaud and Y. Hansmann and A. Harxhi and V. Kirova and I. Masse-Chabredier and S. Oncu and A. Sener and R. Tekin and O. Deveci and O. Karabay and C. Agalar",
year = "2014",
month = "10",
day = "1",
doi = "10.1111/1469-0691.12478",
language = "English (US)",
volume = "20",
pages = "O600--O608",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - The microbiological diagnosis of tuberculous meningitis

T2 - Results of Haydarpasa-1 study

AU - Erdem, H.

AU - Ozturk-Engin, D.

AU - Elaldi, N.

AU - Gulsun, S.

AU - Sengoz, G.

AU - Crisan, A.

AU - Johansen, I. S.

AU - Inan, A.

AU - Nechifor, M.

AU - Al-Mahdawi, A.

AU - Civljak, R.

AU - Ozguler, M.

AU - Savic, B.

AU - Ceran, N.

AU - Cacopardo, B.

AU - Inal, A. S.

AU - Namiduru, M.

AU - Dayan, S.

AU - Kayabas, U.

AU - Parlak, E.

AU - Khalifa, A.

AU - Kursun, E.

AU - Sipahi, O. R.

AU - Yemisen, M.

AU - Akbulut, A.

AU - Bitirgen, M.

AU - Dulovic, O.

AU - Kandemir, B.

AU - Luca, C.

AU - Parlak, M.

AU - Stahl, J. P.

AU - Pehlivanoglu, F.

AU - Simeon, S.

AU - Ulu-Kilic, A.

AU - Yasar, K.

AU - Yilmaz, G.

AU - Yilmaz, E.

AU - Beovic, B.

AU - Catroux, M.

AU - Lakatos, B.

AU - Sunbul, M.

AU - Oncul, O.

AU - Alabay, S.

AU - Sahin-Horasan, E.

AU - Kose, S.

AU - Shehata, G.

AU - Andre, K.

AU - Alp, A.

AU - Ćosić, G.

AU - Cem Gul, H.

AU - Karakas, A.

AU - Chadapaud, S.

AU - Hansmann, Y.

AU - Harxhi, A.

AU - Kirova, V.

AU - Masse-Chabredier, I.

AU - Oncu, S.

AU - Sener, A.

AU - Tekin, R.

AU - Deveci, O.

AU - Karabay, O.

AU - Agalar, C.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-γ release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p 

AB - We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-γ release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p 

KW - PCR

KW - Culture

KW - Diagnosis

KW - Meningitis

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=84913605718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84913605718&partnerID=8YFLogxK

U2 - 10.1111/1469-0691.12478

DO - 10.1111/1469-0691.12478

M3 - Article

C2 - 24849547

AN - SCOPUS:84913605718

VL - 20

SP - O600-O608

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 10

ER -