The Microbead: A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System

Adam Khalifa, Yasha Karimi, Qihong Wang, Sahithi Garikapati, Webert Montlouis, Milutin Stanacevic, Nitish V Thakor, Ralph Etienne-Cummings

Research output: Contribution to journalArticle

Abstract

An implant that can electrically stimulate neurons across different depths and regions of the brain currently does not exist as it poses a number of obstacles that need to be solved. In order to address the challenges, this paper presents the concept of “microbead,” a fully integrated wirelessly powered neural device that allows for spatially selective activation of neural tissue. The prototype chip is fabricated in 130-nm CMOS technology and currently measures 200 μm × 200 μm, which represents the smallest remotely powered stimulator to date. The system is validated experimentally in a rat by stimulating the sciatic nerve with 195-μs current pulses. To power the ultrasmall on-silicon coil, 36-dBm source power is provided to a highly optimized transmitter (Tx) coil at a coupling distance of 5 mm. In order to satisfy the strict power limit for safe use in human subjects, a pulsed powering scheme is implemented that enables a significant decrease in the average power emitted from the Tx.

Original languageEnglish (US)
JournalIEEE Transactions on Biomedical Circuits and Systems
DOIs
StateAccepted/In press - Mar 14 2018

Fingerprint

Neurons
Rats
Transmitters
Brain
Chemical activation
Tissue
Silicon

Keywords

  • Miniaturization
  • neurostimulator
  • on-chip coil
  • specific absorption rate
  • wireless power transfer

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Khalifa, A., Karimi, Y., Wang, Q., Garikapati, S., Montlouis, W., Stanacevic, M., ... Etienne-Cummings, R. (Accepted/In press). The Microbead: A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System. IEEE Transactions on Biomedical Circuits and Systems. https://doi.org/10.1109/TBCAS.2018.2802443

The Microbead : A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System. / Khalifa, Adam; Karimi, Yasha; Wang, Qihong; Garikapati, Sahithi; Montlouis, Webert; Stanacevic, Milutin; Thakor, Nitish V; Etienne-Cummings, Ralph.

In: IEEE Transactions on Biomedical Circuits and Systems, 14.03.2018.

Research output: Contribution to journalArticle

Khalifa, Adam ; Karimi, Yasha ; Wang, Qihong ; Garikapati, Sahithi ; Montlouis, Webert ; Stanacevic, Milutin ; Thakor, Nitish V ; Etienne-Cummings, Ralph. / The Microbead : A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System. In: IEEE Transactions on Biomedical Circuits and Systems. 2018.
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