The methylation locus and frequency pattern on p16INK4a gene promoter CpG in epidermis of patients with psoriasis

Min Chen, Pan Gen Cui, Xu Yao, Yuan Hua Cao, Juan Qin Gong, An Sheng Li, Zhi Qiang Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the CpG methylation locus and frequency pattern on p16INK4a gene promoter in epidermis of p16INK4a methylated patients with psoriasis vulgaris. Methods: The DNA specimens were obtained from epidermal lesion of 50 plaque psoriatic patients. Methylation specific PCR and DNA sequencing were used to detect the frequency and locus of methylation in p16INK4a gene promoter region. Results: Approximately 50% CpG was methylated in p16INK4a methylated patients, methylation was found in specifical locus of p16INK4a gene promoter. Conclusion: The distinct methylation pattern is showed on the p16INK4a gene promoter region in patients with psoriasis.

Original languageEnglish (US)
Pages (from-to)674-676
Number of pages3
JournalChinese Journal of Medical Genetics
Volume24
Issue number6
StatePublished - Dec 10 2007
Externally publishedYes

Keywords

  • CpG methylation
  • p16 gene
  • Promoter
  • Psoriasis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Bioengineering

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