TY - JOUR
T1 - The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury
AU - McDonald, John W.
AU - Schoepp, Darryle D.
PY - 1992/5/14
Y1 - 1992/5/14
N2 - The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.
AB - The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.
KW - Excitatory amino acid
KW - Excitotoxicity
KW - Metabotropic receptors
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U2 - 10.1016/0014-2999(92)90058-C
DO - 10.1016/0014-2999(92)90058-C
M3 - Article
C2 - 1383003
AN - SCOPUS:0026579128
SN - 0014-2999
VL - 215
SP - 353
EP - 354
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -