The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury

John W. McDonald, Darryle D. Schoepp

Research output: Contribution to journalArticlepeer-review

Abstract

The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.

Original languageEnglish (US)
Pages (from-to)353-354
Number of pages2
JournalEuropean Journal of Pharmacology
Volume215
Issue number2-3
DOIs
StatePublished - May 14 1992

Keywords

  • Excitatory amino acid
  • Excitotoxicity
  • Metabotropic receptors

ASJC Scopus subject areas

  • Pharmacology

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