The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Jennifer L. Dearborn; David Knopman; A. Richey Sharrett; Andrea L.C. Schneider; Clifford R. Jack; Laura H. Coker; Alvaro Alonso; Elizabeth Selvin; Thomas H. Mosley; Lynne E. Wagenknecht; Beverly G. Windham; Rebecca F. Gottesman

doi:10.1159/000362265

The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Jennifer L. Dearborn, David Knopman, A. Richey Sharrett, Andrea L.C. Schneider, Clifford R. Jack, Laura H. Coker, Alvaro Alonso, Elizabeth Selvin, Thomas H. Mosley, Lynne E. Wagenknecht, Beverly G. Windham, Rebecca F. Gottesman

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).

Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).

Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.

Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.

Original language	English (US)
Pages (from-to)	337-346
Number of pages	10
Journal	Dementia and Geriatric Cognitive Disorders
Volume	38
DOIs	https://doi.org/10.1159/000362265
State	Published - Nov 7 2014

Keywords

Cognition
Cognitive decline
Dementia
Hypertension
Metabolic syndrome
Obesity

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

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Dearborn, J. L., Knopman, D., Sharrett, A. R., Schneider, A. L. C., Jack, C. R., Coker, L. H., Alonso, A., Selvin, E., Mosley, T. H., Wagenknecht, L. E., Windham, B. G., & Gottesman, R. F. (2014). The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC). Dementia and Geriatric Cognitive Disorders, 38, 337-346. https://doi.org/10.1159/000362265

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abstract = "Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.",

keywords = "Cognition, Cognitive decline, Dementia, Hypertension, Metabolic syndrome, Obesity",

author = "Dearborn, {Jennifer L.} and David Knopman and Sharrett, {A. Richey} and Schneider, {Andrea L.C.} and Jack, {Clifford R.} and Coker, {Laura H.} and Alvaro Alonso and Elizabeth Selvin and Mosley, {Thomas H.} and Wagenknecht, {Lynne E.} and Windham, {Beverly G.} and Gottesman, {Rebecca F.}",

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doi = "10.1159/000362265",

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AU - Dearborn, Jennifer L.

AU - Knopman, David

AU - Sharrett, A. Richey

AU - Schneider, Andrea L.C.

AU - Jack, Clifford R.

AU - Coker, Laura H.

AU - Alonso, Alvaro

AU - Selvin, Elizabeth

AU - Mosley, Thomas H.

AU - Wagenknecht, Lynne E.

AU - Windham, Beverly G.

AU - Gottesman, Rebecca F.

PY - 2014/11/7

Y1 - 2014/11/7

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AB - Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.

KW - Cognition

KW - Cognitive decline

KW - Dementia

KW - Hypertension

KW - Metabolic syndrome

KW - Obesity

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The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Abstract

Keywords

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