The metabolic reprogramming and vulnerability of SF3B1 mutations

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Abstract

Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear. Our recent study of isogenic human cells demonstrated that SF3B1MUT induces reprogramming of energy metabolism and a targetable vulnerability to deprivation of the nonessential amino acid serine.

Original languageEnglish (US)
Article number1697619
JournalMolecular and Cellular Oncology
Volume7
Issue number3
DOIs
StatePublished - May 3 2020

Keywords

  • PHGDH
  • SF3B1
  • metabolism
  • serine
  • spliceosome

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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