The Metabolic Interplay between Cancer and Other Diseases

Anne Le, Sunag Udupa, Cissy Zhang

Research output: Contribution to journalReview articlepeer-review


Over the past decade, knowledge of cancer metabolism has expanded exponentially and has provided several clinically relevant targets for cancer therapy. Although these current approaches have shown promise, there are very few studies showing how seemingly unrelated metabolic processes in other diseases can readily occur in cancer. Moreover, the striking metabolic overlap between cancer and other diseases such as diabetes, cardiovascular, neurological, obesity, and aging has provided key therapeutic strategies that have even begun to be translated into clinical trials. These promising results necessitate consideration of the interconnected metabolic network while studying the metabolism of cancer. This review article discusses how cancer metabolism is intertwined with systemic metabolism and how knowledge from other diseases can help to broaden therapeutic opportunities for cancer.

Original languageEnglish (US)
Pages (from-to)809-821
Number of pages13
JournalTrends in Cancer
Issue number12
StatePublished - Dec 2019


  • aging
  • cancer metabolism
  • cardiovascular diseases
  • diabetes
  • neurological diseases
  • obesity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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