The membrane-anchored serine protease Prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity

Diane E. Peters, Roman Szabo, Stine Friis, Natalia A. Shylo, Katiuchia Uzzun Sales, Kenn Holmbeck, Thomas H. Bugge

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prostasin is a membrane-anchored serine protease with essential functions in epithelial development and homeostasis. Results: Mice expressing enzymatically inactive endogenous prostasin, unlike prostasin null mice, display normal tissue development and homeostasis. Conclusion: Essential in vivo functions of prostasin are independent of the catalytic activity of prostasin. Significance: Prostasin may have a unique role as an allosteric regulator of other membrane-anchored proteases.

Original languageEnglish (US)
Pages (from-to)14740-14749
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number21
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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