The melanocytotoxicity of γ-L-glutaminyl-4-hydroxybenzene. A study of the pigmented cells in the mouse eye

E. H. Koo, P. C. Burger, F. S. Vogel

Research output: Contribution to journalArticle

Abstract

The administration of γ-L-glutaminyl-4-hydroxybenzene (GHB) to neonatal black mice resulted in selective necrosis of the melanocytes in the choroid but had no apparent effect on the retinal pigment epithelium and pigmented cells of the iris and ciliary body. No changes were noted in any of the ocular melanocytes when GHB was administered to adult black mice or neonatal albino mice. The administration of p-aminophenol, which may be a metabolite of GHB in mammalian cells, produced identical cytologic changes in the eyes of neonatal black mice. The findings indicate that in the presence of an active melanogenic environment, the metabolism of GHB generates products that are promptly cytolytic. In the immature retina of both black and albino mice, the administration of GHB also resulted in scattered necrosis in the inner layer of the developing neuroblastic cells in the form of cellular condensation. This effect, which is independent of the process of melanogenesis, could not be elicited beyond the fifth postnatal day and may represent a quantitative exaggeration of a normal cellular phenomenon.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalAmerican Journal of Pathology
Volume102
Issue number1
StatePublished - 1981
Externally publishedYes

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Phenol
Melanocytes
Necrosis
Ciliary Body
Choroid
Retinal Pigment Epithelium
Iris
Retina

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The melanocytotoxicity of γ-L-glutaminyl-4-hydroxybenzene. A study of the pigmented cells in the mouse eye. / Koo, E. H.; Burger, P. C.; Vogel, F. S.

In: American Journal of Pathology, Vol. 102, No. 1, 1981, p. 40-48.

Research output: Contribution to journalArticle

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