The mechanism of eukaryotic translation initiation: New insights and challenges

Alan G. Hinnebusch, Jon R. Lorsch

Research output: Contribution to journalArticlepeer-review

Abstract

Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs fromin vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Biology
Volume4
Issue number10
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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