The mechanism of action of topical retinoids

Research output: Contribution to journalArticle

Abstract

UV irradiation of human skin sets in motion a complex sequence of events that causes damage to the dermal matrix. When topical tretinoin is applied to human skin, any collagen deficiency existing in photoaged skin is remedied at least partially, and the skin is primed to prevent further matrix degradation induced by solar UV. Retinoids, therefore, have become essential in the treatment and prevention of photoaging. This article describes the mechanism of action of retinoids, including how they are mediated through retinoic acid receptors (RARs) and retinoid X receptors (RXRs), how they block inflammation mediators, and how production of procollagen is increased to augment the formation of types I and III collagen. Three naturally occurring retinoids are reviewed.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalCutis
Volume75
Issue number2 SUPPL.
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Retinoids
Skin
Retinoid X Receptors
Procollagen
Inflammation Mediators
Retinoic Acid Receptors
Collagen Type III
Collagen Type I
Tretinoin
Collagen

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

The mechanism of action of topical retinoids. / Kang, Sewon.

In: Cutis, Vol. 75, No. 2 SUPPL., 02.2005, p. 10-13.

Research output: Contribution to journalArticle

Kang, S 2005, 'The mechanism of action of topical retinoids', Cutis, vol. 75, no. 2 SUPPL., pp. 10-13.
Kang, Sewon. / The mechanism of action of topical retinoids. In: Cutis. 2005 ; Vol. 75, No. 2 SUPPL. pp. 10-13.
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