The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Leticia Vittone; Liliana E. Chiappe; Maria I. Argel; H. E. Cingolani; Gladys E. Chiappe

doi:10.1007/BF01965986

The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Leticia Vittone, Liliana E. Chiappe, Maria I. Argel, H. E. Cingolani, Gladys E. Chiappe

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10^-4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

Original language	English (US)
Pages (from-to)	1088-1090
Number of pages	3
Journal	Experientia
Volume	36
Issue number	9
DOIs	https://doi.org/10.1007/BF01965986
State	Published - Sep 1980
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF01965986

Cite this

@article{e933004a9d134effa142f6b078ec3944,

title = "The mechanical and biochemical effects of pentoxifylline on the perfused rat heart",

abstract = "Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10-4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.",

author = "Leticia Vittone and Chiappe, {Liliana E.} and Argel, {Maria I.} and Cingolani, {H. E.} and Chiappe, {Gladys E.}",

year = "1980",

month = sep,

doi = "10.1007/BF01965986",

language = "English (US)",

volume = "36",

pages = "1088--1090",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Birkhauser Verlag Basel",

number = "9",

}

TY - JOUR

T1 - The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

AU - Vittone, Leticia

AU - Chiappe, Liliana E.

AU - Argel, Maria I.

AU - Cingolani, H. E.

AU - Chiappe, Gladys E.

PY - 1980/9

Y1 - 1980/9

N2 - Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10-4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

AB - Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10-4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

UR - http://www.scopus.com/inward/record.url?scp=0018957205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018957205&partnerID=8YFLogxK

U2 - 10.1007/BF01965986

DO - 10.1007/BF01965986

M3 - Article

C2 - 6252042

AN - SCOPUS:0018957205

SN - 1420-682X

VL - 36

SP - 1088

EP - 1090

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 9

ER -

The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this