The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Leticia Vittone, Liliana E. Chiappe, Maria I. Argel, H. E. Cingolani, Gladys E. Chiappe

Research output: Contribution to journalArticlepeer-review

Abstract

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10-4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

Original languageEnglish (US)
Pages (from-to)1088-1090
Number of pages3
JournalExperientia
Volume36
Issue number9
DOIs
StatePublished - Sep 1 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The mechanical and biochemical effects of pentoxifylline on the perfused rat heart'. Together they form a unique fingerprint.

Cite this