The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Leticia Vittone, Liliana E. Chiappe, Maria I. Argel, H. E. Cingolani, Gladys E. Chiappe

Research output: Contribution to journalArticle

Abstract

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10-4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

Original languageEnglish (US)
Pages (from-to)1088-1090
Number of pages3
JournalExperientia
Volume36
Issue number9
DOIs
StatePublished - Sep 1980
Externally publishedYes

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Pentoxifylline
Rats
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Cyclic AMP-Dependent Protein Kinases
Perfusion
Heart Rate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vittone, L., Chiappe, L. E., Argel, M. I., Cingolani, H. E., & Chiappe, G. E. (1980). The mechanical and biochemical effects of pentoxifylline on the perfused rat heart. Experientia, 36(9), 1088-1090. https://doi.org/10.1007/BF01965986

The mechanical and biochemical effects of pentoxifylline on the perfused rat heart. / Vittone, Leticia; Chiappe, Liliana E.; Argel, Maria I.; Cingolani, H. E.; Chiappe, Gladys E.

In: Experientia, Vol. 36, No. 9, 09.1980, p. 1088-1090.

Research output: Contribution to journalArticle

Vittone, L, Chiappe, LE, Argel, MI, Cingolani, HE & Chiappe, GE 1980, 'The mechanical and biochemical effects of pentoxifylline on the perfused rat heart', Experientia, vol. 36, no. 9, pp. 1088-1090. https://doi.org/10.1007/BF01965986
Vittone L, Chiappe LE, Argel MI, Cingolani HE, Chiappe GE. The mechanical and biochemical effects of pentoxifylline on the perfused rat heart. Experientia. 1980 Sep;36(9):1088-1090. https://doi.org/10.1007/BF01965986
Vittone, Leticia ; Chiappe, Liliana E. ; Argel, Maria I. ; Cingolani, H. E. ; Chiappe, Gladys E. / The mechanical and biochemical effects of pentoxifylline on the perfused rat heart. In: Experientia. 1980 ; Vol. 36, No. 9. pp. 1088-1090.
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