The matrix metalloproteinases and CNS plasticity: An overview

E. A. Milward, C. Fitzsimmons, A. Szklarczyk, K. Conant

Research output: Contribution to journalArticle

Abstract

The matrix metalloproteinases (MMPs) are expressed in response to pro-inflammatory stimuli and other triggers. The MMPs cleave numerous substrates including extracellular matrix components, cytokines and growth factors. In the CNS, while most studied in the context of disease, the many physiological functions of the MMPs are now becoming appreciated. This review provides an overview of the growing body of evidence for physiological roles of MMPs both in CNS development and in CNS plasticity in normal brain functioning, including learning and memory, as well as in CNS repair and reorganization as part of the neuroimmune response to injury.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalJournal of Neuroimmunology
Volume187
Issue number1-2
DOIs
StatePublished - Jul 2007

Fingerprint

Matrix Metalloproteinases
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Learning
Cytokines
Wounds and Injuries
Brain

Keywords

  • CNS plasticity
  • Cognition
  • Development
  • Injury
  • Matrix metalloproteinases
  • TIMPs

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Milward, E. A., Fitzsimmons, C., Szklarczyk, A., & Conant, K. (2007). The matrix metalloproteinases and CNS plasticity: An overview. Journal of Neuroimmunology, 187(1-2), 9-19. https://doi.org/10.1016/j.jneuroim.2007.04.010

The matrix metalloproteinases and CNS plasticity : An overview. / Milward, E. A.; Fitzsimmons, C.; Szklarczyk, A.; Conant, K.

In: Journal of Neuroimmunology, Vol. 187, No. 1-2, 07.2007, p. 9-19.

Research output: Contribution to journalArticle

Milward, EA, Fitzsimmons, C, Szklarczyk, A & Conant, K 2007, 'The matrix metalloproteinases and CNS plasticity: An overview', Journal of Neuroimmunology, vol. 187, no. 1-2, pp. 9-19. https://doi.org/10.1016/j.jneuroim.2007.04.010
Milward, E. A. ; Fitzsimmons, C. ; Szklarczyk, A. ; Conant, K. / The matrix metalloproteinases and CNS plasticity : An overview. In: Journal of Neuroimmunology. 2007 ; Vol. 187, No. 1-2. pp. 9-19.
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