The many sounds of T lymphocyte silence

Ignacio Melero, Ainhoa Arina, Lieping Chen

Research output: Contribution to journalArticle

Abstract

It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initially, dendritic cells and regulatory T cells appear to play critical roles. In addition, T cell immunity is tightly regulated by a molecular network of cytokines and cell receptor interactions by the opposed surfaces of antigen-presenting cells and T cells. Recognition of a specific antigen is therefore shaped and tuned by co-stimulatory and co-inhibitory receptor-ligand pairs. At last, immunologists are beginning to exploit the rules governing these assorted sounds of T cell silence.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalImmunologic Research
Volume33
Issue number2
DOIs
StatePublished - Nov 2005

Keywords

  • Anergy
  • Costimulation
  • Immunological ignorance
  • Immunotherapy
  • T cell
  • Tolerance

ASJC Scopus subject areas

  • Immunology

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