The mannose-binding lectin (MBL2) haplotype and breast cancer: An association study in African-American and Caucasian women

Toralf Bernig, Brenda J. Boersma, Tiffany M. Howe, Robert Welch, Sunita Yadavalli, Brian Staats, Leah E. Mechanic, Stephen J. Chanock, Stefan Ambs

Research output: Contribution to journalArticle

Abstract

Common genetic variants in cancer-related genes contribute to breast cancer. The innate immune system plays a crucial role in the immune surveillance against malignancies, thus it is plausible that genetic variations in key genes of the innate immunity such as the mannose-binding lectin (MBL), MBL2, could influence the risk for breast cancer. We investigated the association of MBL2 genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26 MBL2 single nucleotide polymorphisms (SNPs) in a case-control study of breast cancer [166 African-American (AA) case patients versus 180 controls and 127 Caucasian (CAU) case patients versus 137 controls]. We observed that the A allele of the 3′-UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in AA women [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27-0.81]. Haplotype analysis of MBL2 showed that the frequency of the corresponding 3′ haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3′ STP) was lower in cases than controls among AA women (0.15 versus 0.21; P = 0.02) suggesting a protective effect after adjusting for covariates (OR = 0.51, 95% CI = 0.29-0.88, P = 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3′-UTR of MBL2 might influence the risk for breast cancer in AA women, probably in interaction with the 5′ secretor haplotypes that are associated with high concentrations of MBL.

Original languageEnglish (US)
Pages (from-to)828-836
Number of pages9
JournalCarcinogenesis
Volume28
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

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Mannose-Binding Lectin
African Americans
Haplotypes
Breast Neoplasms
Single Nucleotide Polymorphism
3' Untranslated Regions
Odds Ratio
Genotype
Confidence Intervals
Neoplasm Genes
Innate Immunity
Case-Control Studies
Immune System
Alleles
Genes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Bernig, T., Boersma, B. J., Howe, T. M., Welch, R., Yadavalli, S., Staats, B., ... Ambs, S. (2007). The mannose-binding lectin (MBL2) haplotype and breast cancer: An association study in African-American and Caucasian women. Carcinogenesis, 28(4), 828-836. https://doi.org/10.1093/carcin/bgl198

The mannose-binding lectin (MBL2) haplotype and breast cancer : An association study in African-American and Caucasian women. / Bernig, Toralf; Boersma, Brenda J.; Howe, Tiffany M.; Welch, Robert; Yadavalli, Sunita; Staats, Brian; Mechanic, Leah E.; Chanock, Stephen J.; Ambs, Stefan.

In: Carcinogenesis, Vol. 28, No. 4, 04.2007, p. 828-836.

Research output: Contribution to journalArticle

Bernig, T, Boersma, BJ, Howe, TM, Welch, R, Yadavalli, S, Staats, B, Mechanic, LE, Chanock, SJ & Ambs, S 2007, 'The mannose-binding lectin (MBL2) haplotype and breast cancer: An association study in African-American and Caucasian women', Carcinogenesis, vol. 28, no. 4, pp. 828-836. https://doi.org/10.1093/carcin/bgl198
Bernig, Toralf ; Boersma, Brenda J. ; Howe, Tiffany M. ; Welch, Robert ; Yadavalli, Sunita ; Staats, Brian ; Mechanic, Leah E. ; Chanock, Stephen J. ; Ambs, Stefan. / The mannose-binding lectin (MBL2) haplotype and breast cancer : An association study in African-American and Caucasian women. In: Carcinogenesis. 2007 ; Vol. 28, No. 4. pp. 828-836.
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