The management of thyroid and parathyroid cancer

Nasheed M. Hossain; Colleen Veloski; Ranee Mehra

doi:10.1007/978-3-319-27601-4_40

The management of thyroid and parathyroid cancer

Nasheed M. Hossain, Colleen Veloski, Ranee Mehra

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Thyroid and parathyroid cancers are both relatively uncommon malignancies; however, the yearly incidence of thyroid cancer has nearly tripled since 1975. The mainstay of treatment of these endocrine malignancies has been surgical resection and radioactive iodine treatment for thyroid cancer. Differentiated thyroid cancers encompass papillary and follicular carcinomas and are responsive to radioactive iodine treatment and TSH suppression, in contrast to medullary thyroid cancer. There is now a greater understanding of the molecular pathogenesis of differentiated thyroid cancers, poorly differentiated and anaplastic thyroid cancers, and medullary thyroid cancer. This has prompted numerous phase studies utilizing oral biologically targeted agents that inhibit a variety of tyrosine kinase inhibitors, such as the vascular endothelial growth factor receptors, c-Kit, RET, and PDGFR. This review will discuss the epidemiology, histologies, pathogenesis, and issues in management of thyroid and parathyroid cancers.

Original language	English (US)
Title of host publication	Head and Neck Cancer
Subtitle of host publication	Multimodality Management, Second Edition
Publisher	Springer International Publishing
Pages	673-692
Number of pages	20
ISBN (Electronic)	9783319276014
ISBN (Print)	9783319275994
DOIs	https://doi.org/10.1007/978-3-319-27601-4_40
State	Published - Jan 1 2016

Keywords

Parathyroid cancer
Thyroid cancer
Tyrosine kinase inhibitors

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-319-27601-4_40

Cite this

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AB - Thyroid and parathyroid cancers are both relatively uncommon malignancies; however, the yearly incidence of thyroid cancer has nearly tripled since 1975. The mainstay of treatment of these endocrine malignancies has been surgical resection and radioactive iodine treatment for thyroid cancer. Differentiated thyroid cancers encompass papillary and follicular carcinomas and are responsive to radioactive iodine treatment and TSH suppression, in contrast to medullary thyroid cancer. There is now a greater understanding of the molecular pathogenesis of differentiated thyroid cancers, poorly differentiated and anaplastic thyroid cancers, and medullary thyroid cancer. This has prompted numerous phase studies utilizing oral biologically targeted agents that inhibit a variety of tyrosine kinase inhibitors, such as the vascular endothelial growth factor receptors, c-Kit, RET, and PDGFR. This review will discuss the epidemiology, histologies, pathogenesis, and issues in management of thyroid and parathyroid cancers.

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The management of thyroid and parathyroid cancer

Abstract

Keywords

ASJC Scopus subject areas

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