The management of neurotrophic keratitis

Samir Jabbour; Christopher Ashton; Shafi Balal; Abigail Kaye; Sajjad Ahmad

doi:10.1097/ICU.0000000000000766

The management of neurotrophic keratitis

Samir Jabbour, Christopher Ashton, Shafi Balal, Abigail Kaye, Sajjad Ahmad

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of reviewThe management of neurotrophic keratitis (NK) has evolved in the last decade. The present article reviews updated management guidelines of this entity, as well as future innovations in the field.Recent findingsThe advent of confocal microscopy has allowed for the first time to image corneal nerves. In addition, multiple novel topical treatments such as nerve growth factor have improved the prognosis of this disease, with many other in the pipeline. Finally, corneal nerve restoration is now possible with corneal neurotization procedures.SummaryMany novel treatments based on agents that stimulate nerve regrowth are now available to treat NK. Improvement in neurotization procedures could also address advanced stages of this disease with surgery.

Original language	English (US)
Pages (from-to)	362-368
Number of pages	7
Journal	Current opinion in ophthalmology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1097/ICU.0000000000000766
State	Published - Jul 1 2021

Keywords

corneal nerves
corneal neurotization
nerve growth factor
neurotrophic keratitis
persistent epithelial defects

ASJC Scopus subject areas

Ophthalmology

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10.1097/ICU.0000000000000766

Cite this

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title = "The management of neurotrophic keratitis",

abstract = "Purpose of reviewThe management of neurotrophic keratitis (NK) has evolved in the last decade. The present article reviews updated management guidelines of this entity, as well as future innovations in the field.Recent findingsThe advent of confocal microscopy has allowed for the first time to image corneal nerves. In addition, multiple novel topical treatments such as nerve growth factor have improved the prognosis of this disease, with many other in the pipeline. Finally, corneal nerve restoration is now possible with corneal neurotization procedures.SummaryMany novel treatments based on agents that stimulate nerve regrowth are now available to treat NK. Improvement in neurotization procedures could also address advanced stages of this disease with surgery.",

keywords = "corneal nerves, corneal neurotization, nerve growth factor, neurotrophic keratitis, persistent epithelial defects",

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AU - Jabbour, Samir

AU - Ashton, Christopher

AU - Balal, Shafi

AU - Kaye, Abigail

AU - Ahmad, Sajjad

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Purpose of reviewThe management of neurotrophic keratitis (NK) has evolved in the last decade. The present article reviews updated management guidelines of this entity, as well as future innovations in the field.Recent findingsThe advent of confocal microscopy has allowed for the first time to image corneal nerves. In addition, multiple novel topical treatments such as nerve growth factor have improved the prognosis of this disease, with many other in the pipeline. Finally, corneal nerve restoration is now possible with corneal neurotization procedures.SummaryMany novel treatments based on agents that stimulate nerve regrowth are now available to treat NK. Improvement in neurotization procedures could also address advanced stages of this disease with surgery.

AB - Purpose of reviewThe management of neurotrophic keratitis (NK) has evolved in the last decade. The present article reviews updated management guidelines of this entity, as well as future innovations in the field.Recent findingsThe advent of confocal microscopy has allowed for the first time to image corneal nerves. In addition, multiple novel topical treatments such as nerve growth factor have improved the prognosis of this disease, with many other in the pipeline. Finally, corneal nerve restoration is now possible with corneal neurotization procedures.SummaryMany novel treatments based on agents that stimulate nerve regrowth are now available to treat NK. Improvement in neurotization procedures could also address advanced stages of this disease with surgery.

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KW - nerve growth factor

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KW - persistent epithelial defects

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The management of neurotrophic keratitis

Abstract

Keywords

ASJC Scopus subject areas

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