The Malignant Melanoma of Hamsters II. Growth and Morphology of a Transplanted Melanotic and Amelanotic Tumor in Tissue Culture

S. A. Rosenberg, M. Kodani, J. C. Rosenberg

Research output: Contribution to journalArticle

Abstract

The melanotic and amelanotic transplanted hamster melanoma (Fortner) has been grown in tissue culture. Four main cell types are observed; the melanocyte, fibrocyte, macrophage, and an unusual form of giant fibrocytic cell. The latter often attains a diameter of 102 μ and can be seen to contain intact melanocytes within its cytoplasm. It is demonstrated that these melanocytes are ingested and subsequently disintegrate within the giant cell. This cell type has previously been noted in histologic preparations of human melanomas. It has not previously been described in tissue culture.

Original languageEnglish (US)
Pages (from-to)632-635
Number of pages4
JournalCancer Research
Volume21
Issue number5
StatePublished - Jun 1 1961

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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