The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia

Faith Dickerson; John Boronow; Cassie Stallings; Andrea Origoni; Robert Yolken

doi:10.1016/j.schres.2006.08.015

The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia

Faith Dickerson, John Boronow, Cassie Stallings, Andrea Origoni, Robert Yolken

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p < 0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia.

Original language	English (US)
Pages (from-to)	173-176
Number of pages	4
Journal	Schizophrenia Research
Volume	89
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2006.08.015
State	Published - Jan 2007

Keywords

Cognitive functioning
Genetic
Immune response
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2006.08.015

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title = "The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia",

abstract = "Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p < 0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia.",

keywords = "Cognitive functioning, Genetic, Immune response, Schizophrenia",

author = "Faith Dickerson and John Boronow and Cassie Stallings and Andrea Origoni and Robert Yolken",

note = "Funding Information: The authors thank Ann Cusic, Flora Leister, and Elizabeth Rubalcaba for assistance in performing the assays. The work was supported by the Stanley Medical Research Institute.",

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AU - Dickerson, Faith

AU - Boronow, John

AU - Stallings, Cassie

AU - Origoni, Andrea

AU - Yolken, Robert

N1 - Funding Information: The authors thank Ann Cusic, Flora Leister, and Elizabeth Rubalcaba for assistance in performing the assays. The work was supported by the Stanley Medical Research Institute.

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N2 - Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p < 0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia.

AB - Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p < 0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia.

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KW - Genetic

KW - Immune response

KW - Schizophrenia

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The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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