The lung in sickle cell disease

H. M. Haupt, G. W. Moore, T. W. Bauer, G. M. Hutchins

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    Abstract

    Patients with sickle cell disease (SCD) often present with acute pulmonary complications, which may have a protracted course. Morphologic observations of SCD patients at autopsy suggested a role of tissue necrosis in the failure of pulmonary infiltrates to resolve with therapy. Infarction of pulmonary parenchyma was seen in regions where alveolar gas exchange was compromised by edema or exudates. We reviewed the clinical and pathologic features of 72 patients with sickle cell disease (59 SS, 12 SC, and 1 S-Thal) autopsied at The Johns Hopkins Hospital and compared 72 age-sex-race matched controls. Alveolar wall necrosis attributed to vascular obstruction by sickling occurred in areas where the airspace was occupied by edema or inflammatory exudate. Twelve (17 percent) SCD patients had alveolar wall necrosis, three (27 percent) among the 11 patients with bronchopneumonia and nine (17 percent) among the 54 patients with edema. Only four (6 percent) control patients had alveolar wall necrosis, all (20 percent) among the 21 patients with bronchopneumonia. Thus, alveolar wall necrosis was significantly more frequent among SCD patients (P

    Original languageEnglish (US)
    Pages (from-to)332-337
    Number of pages6
    JournalChest
    Volume81
    Issue number3
    StatePublished - 1982

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    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine

    Cite this

    Haupt, H. M., Moore, G. W., Bauer, T. W., & Hutchins, G. M. (1982). The lung in sickle cell disease. Chest, 81(3), 332-337.