Abstract
Study objectives: To determine the efficacy of the lung as an alternative route of delivery for insulin in controlling glucose below diabetic levels (11.2 mmol/L) 2 h after the ingestion of a meal in patients with type 2 diabetes mellitus. Design: Single-blinded, nonrandomized, placebo-controlled pilot study consisting of two visits. Setting: A primary care facility. Patients: Seven patients with type 2 diabetes mellitus. Interventions: On the first study visit, fasting glucose levels were normalized. Then, patients inhaled 1.5 U/kg insulin by aerosol into the lungs 5 min before ingesting a test meal. On the second visit, patients inhaled placebo aerosol 5 min before ingesting the same meal. On both visits, plasma samples were collected and analyzed for glucose levels for 3 h during the postprandial state. Measurements and results: No one coughed after inhalation of insulin aerosol or demonstrated hypoglycemia. During the postprandial period, glucose levels were significantly lower at 20 min (5.12 ± 1.08 mmol/L), 1 h (7.87 ± 0.73 mmol/L), 2 h (8.05 ± 1.24 mmol/L) and 3 h (7.50 ± 1.43 mmol/L) following inhalation of insulin than when the placebo was used. Data for the placebo were 10.36 ± 1.23 mmol/L at 20 min, 14.0 ± 1.68 mmol/L at 1 h, 16.18 ± 1.45 mmol/L at 2 h, and 14.37 ± 2.11 mmol/L at 3h (for all comparisons, p <0.05). On the insulin visit, glucose levels were <11.2 mmol/L 2 h after the meal in six of seven patients. None attained this level at the placebo visit. In addition, glucose levels were within the normal postprandial range of <7.84 mmol/L in four of seven patients 2 h after eating on the insulin visit. Conclusions: These results suggest that, once plasma glucose levels are normalized, postprandial glucose levels can be maintained below diabetic levels by delivering 1.5 U/kg insulin into the lungs 5 min before the ingestion of a meal.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1734-1739 |
| Number of pages | 6 |
| Journal | Chest |
| Volume | 114 |
| Issue number | 6 |
| State | Published - 1998 |
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Keywords
- Aerosol
- Diabetes
- Insulin
- Lungs
- Postprandial glucose
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
The Lung As an Alternative Route of Delivery for Insulin in Controlling Postprandial Glucose Levels in Patients with Diabetes. / Laube, Beth L; Benedict, G. William; Dobs, Adrian S.
In: Chest, Vol. 114, No. 6, 1998, p. 1734-1739.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Lung As an Alternative Route of Delivery for Insulin in Controlling Postprandial Glucose Levels in Patients with Diabetes
AU - Laube, Beth L
AU - Benedict, G. William
AU - Dobs, Adrian S
PY - 1998
Y1 - 1998
N2 - Study objectives: To determine the efficacy of the lung as an alternative route of delivery for insulin in controlling glucose below diabetic levels (11.2 mmol/L) 2 h after the ingestion of a meal in patients with type 2 diabetes mellitus. Design: Single-blinded, nonrandomized, placebo-controlled pilot study consisting of two visits. Setting: A primary care facility. Patients: Seven patients with type 2 diabetes mellitus. Interventions: On the first study visit, fasting glucose levels were normalized. Then, patients inhaled 1.5 U/kg insulin by aerosol into the lungs 5 min before ingesting a test meal. On the second visit, patients inhaled placebo aerosol 5 min before ingesting the same meal. On both visits, plasma samples were collected and analyzed for glucose levels for 3 h during the postprandial state. Measurements and results: No one coughed after inhalation of insulin aerosol or demonstrated hypoglycemia. During the postprandial period, glucose levels were significantly lower at 20 min (5.12 ± 1.08 mmol/L), 1 h (7.87 ± 0.73 mmol/L), 2 h (8.05 ± 1.24 mmol/L) and 3 h (7.50 ± 1.43 mmol/L) following inhalation of insulin than when the placebo was used. Data for the placebo were 10.36 ± 1.23 mmol/L at 20 min, 14.0 ± 1.68 mmol/L at 1 h, 16.18 ± 1.45 mmol/L at 2 h, and 14.37 ± 2.11 mmol/L at 3h (for all comparisons, p <0.05). On the insulin visit, glucose levels were <11.2 mmol/L 2 h after the meal in six of seven patients. None attained this level at the placebo visit. In addition, glucose levels were within the normal postprandial range of <7.84 mmol/L in four of seven patients 2 h after eating on the insulin visit. Conclusions: These results suggest that, once plasma glucose levels are normalized, postprandial glucose levels can be maintained below diabetic levels by delivering 1.5 U/kg insulin into the lungs 5 min before the ingestion of a meal.
AB - Study objectives: To determine the efficacy of the lung as an alternative route of delivery for insulin in controlling glucose below diabetic levels (11.2 mmol/L) 2 h after the ingestion of a meal in patients with type 2 diabetes mellitus. Design: Single-blinded, nonrandomized, placebo-controlled pilot study consisting of two visits. Setting: A primary care facility. Patients: Seven patients with type 2 diabetes mellitus. Interventions: On the first study visit, fasting glucose levels were normalized. Then, patients inhaled 1.5 U/kg insulin by aerosol into the lungs 5 min before ingesting a test meal. On the second visit, patients inhaled placebo aerosol 5 min before ingesting the same meal. On both visits, plasma samples were collected and analyzed for glucose levels for 3 h during the postprandial state. Measurements and results: No one coughed after inhalation of insulin aerosol or demonstrated hypoglycemia. During the postprandial period, glucose levels were significantly lower at 20 min (5.12 ± 1.08 mmol/L), 1 h (7.87 ± 0.73 mmol/L), 2 h (8.05 ± 1.24 mmol/L) and 3 h (7.50 ± 1.43 mmol/L) following inhalation of insulin than when the placebo was used. Data for the placebo were 10.36 ± 1.23 mmol/L at 20 min, 14.0 ± 1.68 mmol/L at 1 h, 16.18 ± 1.45 mmol/L at 2 h, and 14.37 ± 2.11 mmol/L at 3h (for all comparisons, p <0.05). On the insulin visit, glucose levels were <11.2 mmol/L 2 h after the meal in six of seven patients. None attained this level at the placebo visit. In addition, glucose levels were within the normal postprandial range of <7.84 mmol/L in four of seven patients 2 h after eating on the insulin visit. Conclusions: These results suggest that, once plasma glucose levels are normalized, postprandial glucose levels can be maintained below diabetic levels by delivering 1.5 U/kg insulin into the lungs 5 min before the ingestion of a meal.
KW - Aerosol
KW - Diabetes
KW - Insulin
KW - Lungs
KW - Postprandial glucose
UR - http://www.scopus.com/inward/record.url?scp=0032240027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032240027&partnerID=8YFLogxK
M3 - Article
C2 - 9872209
AN - SCOPUS:0032240027
VL - 114
SP - 1734
EP - 1739
JO - Chest
JF - Chest
SN - 0012-3692
IS - 6
ER -